Title:
UNIQUE CANCER ASSOCIATED FIBROBLAST SUBSETS PREDICT RESPONSE TO IMMUNOTHERAPY
Document Type and Number:
WIPO Patent Application WO/2022/272245
Kind Code:
A3
Abstract:
Disclosed herein is a method for treating a solid tumor in a subject that involves detecting in a tumor biopsy sample from the subject enrichment of a cancer associated fibroblast (CAF) subset disclosed herein and then treating the subject with an immunotherapy. Also discussed is a method for treating a solid tumor in a subject that involves isolating cancer associated fibroblasts (CAFs) from the subject, isolating and expanding the disclosed subset of CAFs, and administering the expanded CAF subset to the subject in combination with an immunotherapy.
Inventors:
KORRER MICHAEL J (US)
KIM YOUNG J (US)
CALIFANO ANDREA (US)
KIM YOUNG J (US)
CALIFANO ANDREA (US)
Application Number:
PCT/US2022/073056
Publication Date:
February 02, 2023
Filing Date:
June 21, 2022
Export Citation:
Assignee:
UNIV VANDERBILT (US)
UNIV COLUMBIA (US)
UNIV COLUMBIA (US)
International Classes:
G01N33/574; A61K35/12; A61K35/17; A61P35/00; C07K14/47; C07K16/24; C07K16/28; G01N33/483
Foreign References:
| US20200157633A1 | 2020-05-21 | |||
| US20150322530A1 | 2015-11-12 |
Other References:
GUO: "ACTB in cancer", CLIN CHIM ACTA, 22 December 2012 (2012-12-22), pages 39 - 44, XP028970356, DOI: 10.1016fj.cca. 2012.12.01 2
NGUYEN ELIZABETH V., PEREIRA BROOKE A., LAWRENCE MITCHELL G., MA XIUQUAN, REBELLO RICHARD J., CHAN HOWARD, NIRANJAN BIRUNTHI, WU Y: "Proteomic Profiling of Human Prostate Cancer-associated Fibroblasts (CAF) Reveals LOXL2-dependent Regulation of the Tumor Microenvironment", MOLECULAR & CELLULAR PROTEOMICS, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 18, no. 7, 1 July 2019 (2019-07-01), US , pages 1410 - 1427, XP093031201, ISSN: 1535-9476, DOI: 10.1074/mcp.RA119.001496
NGUYEN ELIZABETH V., PEREIRA BROOKE A., LAWRENCE MITCHELL G., MA XIUQUAN, REBELLO RICHARD J., CHAN HOWARD, NIRANJAN BIRUNTHI, WU Y: "Proteomic Profiling of Human Prostate Cancer-associated Fibroblasts (CAF) Reveals LOXL2-dependent Regulation of the Tumor Microenvironment", MOLECULAR & CELLULAR PROTEOMICS, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 18, no. 7, 1 July 2019 (2019-07-01), US , pages 1410 - 1427, XP093031201, ISSN: 1535-9476, DOI: 10.1074/mcp.RA119.001496
Attorney, Agent or Firm:
GILES, P. Brian (US)
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