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Title:
UNIVERSAL INFLUENZA VACCINE USING NUCLEOSIDE-MODIFIELD MRNA
Document Type and Number:
WIPO Patent Application WO/2021/202734
Kind Code:
A3
Abstract:
The present invention relates to compositions and methods for inducing an immune response against influenza virus in a subject. In some embodiments, the present invention provides a composition comprising a nucleoside-modified nucleic acid molecule encoding at least one influenza virus antigen, such as a hemagglutinin antigen or a fragment thereof, neuraminidase antigen or a fragment thereof, nucleoprotein antigen or a fragment thereof, matrix protein 1 antigen or a fragment thereof, or matrix-2 ion channel antigen or a fragment thereof.

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Inventors:
NACHBAGAUER RAFFAEL (US)
PALESE PETER (US)
KRAMMER FLORIAN (US)
GARCIA-SASTRE ADOLFO (US)
FREYN ALEC (US)
PARDI NORBERT (US)
WEISSMAN DREW (US)
Application Number:
PCT/US2021/025174
Publication Date:
November 11, 2021
Filing Date:
March 31, 2021
Export Citation:
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Assignee:
UNIV PENNSYLVANIA (US)
ICAHN SCHOOL MED MOUNT SINAI (US)
NACHBAGAUER RAFFAEL (US)
PALESE PETER (US)
KRAMMER FLORIAN (US)
GARCIA SASTRE ADOLFO (US)
FREYN ALEC W (US)
International Classes:
A61K39/12; A61K39/145; A61P31/16
Foreign References:
US20160166678A12016-06-16
US20190336595A12019-11-07
US20110229518A12011-09-22
Attorney, Agent or Firm:
SINGH, Pallab et al. (US)
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