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Title:
UNIVERSAL METHOD FOR OPTIMIZING COUNTER ANION TO IMPROVE HEMOSTATIC PERFORMANCE OF BIOLOGICAL MATERIAL
Document Type and Number:
WIPO Patent Application WO/2024/045119
Kind Code:
A1
Abstract:
Disclosed herein is a universal method for optimizing counter anions to improve the hemostatic performance of a biological material. Method I is a method for regulating and controlling an electronegative small molecule and a cationic polymer in a one-pot method: dissolving the cationic polymer and the electronegative small molecule to obtain a blended solution, the mass ratio of the cationic polymer to the electronegative small molecule being 1:0.15-2, preparing the obtained blended solution into a gel or a film, or modifying a base material with the blended solution. Method II is a method for regulating and controlling an electronegative small molecule step by step on the surface of a cation: soaking a base material with the cation on the surface in an electronegative small molecule solution for modification: preparing the electronegative small molecule solution, immersing the base material with the cation on the surface into the electronegative small molecule solution, and carrying out washing and drying. The electronegative small molecule is one or a mixture of two or more of sodium methylsulfate, sodium methanesulfonate, sodium N-cyclohexylsulfamate, sodium morpholine ethanesulfonate monohydrate, sodium 3-N(-morpholino)propanesulfonate, sodium 3-morpholino-2-hydroxypropanesulfonate, and gluconic acid.

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Inventors:
XU FU-JIAN (CN)
HU YANG (CN)
YANG XUE (CN)
Application Number:
PCT/CN2022/116464
Publication Date:
March 07, 2024
Filing Date:
September 01, 2022
Export Citation:
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Assignee:
UNIV BEIJING CHEM TECH (CN)
International Classes:
A61L24/04; A61L24/00; A61L24/06; A61L24/08; A61L24/10
Foreign References:
CN113975447A2022-01-28
CN1448189A2003-10-15
CN107362387A2017-11-21
CN106474530A2017-03-08
Attorney, Agent or Firm:
CHONGQING XINHANG INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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