Title:
UNTARGETED AND TARGETED IL-10 FC-FUSION PROTEINS
Document Type and Number:
WIPO Patent Application WO/2020/172631
Kind Code:
A3
Abstract:
The present invention provides untargeted and targeted IL-10-Fc fusion proteins, compositions and methods of use thereof. The targeted IL-10-Fc fusion proteins includes those that bind PD-1, TIGIT, CDS and NKG2D.
Inventors:
MOORE GREGORY (US)
VARMA RAJAT (US)
KIM YOON (US)
RASHID RUMANA (US)
CHANG ERIC (US)
NISTHAL ALEX (US)
DIAZ JUAN (US)
BERNETT MATTHEW (US)
HEDVAT MICHAEL (US)
VARMA RAJAT (US)
KIM YOON (US)
RASHID RUMANA (US)
CHANG ERIC (US)
NISTHAL ALEX (US)
DIAZ JUAN (US)
BERNETT MATTHEW (US)
HEDVAT MICHAEL (US)
Application Number:
PCT/US2020/019363
Publication Date:
October 08, 2020
Filing Date:
February 21, 2020
Export Citation:
Assignee:
XENCOR INC (US)
International Classes:
C07K14/54
Domestic Patent References:
| WO2018005226A2 | 2018-01-04 | |||
| WO2016100788A1 | 2016-06-23 | |||
| WO2014145806A2 | 2014-09-18 | |||
| WO2018071919A1 | 2018-04-19 |
Other References:
YUGANG GUO ET AL: "Purification and characterization of human IL-10/Fc fusion protein expressed in Pichia pastoris", PROTEIN EXPRESSION AND PURIFICATION, vol. 83, 28 March 2012 (2012-03-28), pages 152 - 156, XP055483837, DOI: 10.1016/j.pep.2012.03.012
GREGORY L. MOORE ET AL: "A robust heterodimeric Fc platform engineered for efficient development of bispecific antibodies of multiple formats", METHODS, vol. 154, 1 February 2019 (2019-02-01), NL, pages 38 - 50, XP055625796, ISSN: 1046-2023, DOI: 10.1016/j.ymeth.2018.10.006
QIAO JIAN ET AL: "Targeting Tumors with IL-10 Prevents Dendritic Cell-Mediated CD8+T Cell Apoptosis", CANCER CELL, vol. 35, no. 6, 10 June 2019 (2019-06-10), pages 901, XP085708826, ISSN: 1535-6108, DOI: 10.1016/J.CCELL.2019.05.005
GREGORY L. MOORE ET AL: "A robust heterodimeric Fc platform engineered for efficient development of bispecific antibodies of multiple formats", METHODS, vol. 154, 1 February 2019 (2019-02-01), NL, pages 38 - 50, XP055625796, ISSN: 1046-2023, DOI: 10.1016/j.ymeth.2018.10.006
QIAO JIAN ET AL: "Targeting Tumors with IL-10 Prevents Dendritic Cell-Mediated CD8+T Cell Apoptosis", CANCER CELL, vol. 35, no. 6, 10 June 2019 (2019-06-10), pages 901, XP085708826, ISSN: 1535-6108, DOI: 10.1016/J.CCELL.2019.05.005
Attorney, Agent or Firm:
NG, Jennifer, K. et al. (US)
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