Title:
UP-REGULATION OF BONE MORPHOGENETIC PROTEIN (BMP) GENE EXPRESSION IN BONE CELLS BY ELECTROMAGNETIC SIGNALS
Document Type and Number:
WIPO Patent Application WO2005070136
Kind Code:
A3
Abstract:
Methods and devices are described for the regulation of bone morphogenetic protein gene expression in bone cells via the application of fields generated by specific and selective electric and electromagnetic signals in the treatment of diseased or injured bone. By gene expression is meant the up-regulation or down-regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased bone tissue that include generating specific and selective electric and electromagnetic signals that generate fields optimized for increase of bone morphogenetic protein gene expression and exposing bone to the fields generated by specific and selective signals so as to regulate bone morphogenetic protein gene expression in such bone tissue. The resulting methods and devices are useful for the targeted treatment of bone fractures, fractures at risk, delayed unions, nonunion of fractures, bone defects, spine fusions, osteonecrosis or avascular necrosis, as an adjunct to other therapies in the treatment of one or all of the above, and in the treatment of osteoporosis.
Inventors:
BRIGHTON CARL T (US)
Application Number:
PCT/US2005/000793
Publication Date:
October 06, 2005
Filing Date:
January 11, 2005
Export Citation:
Assignee:
UNIV PENNSYLVANIA (US)
BRIGHTON CARL T (US)
BRIGHTON CARL T (US)
International Classes:
A01N63/00; A61N1/32; A61N1/40; C07K14/51; C12N5/02; C12N5/07; C12N5/071; C12N5/077; C12N13/00; (IPC1-7): C12N5/02; A01N63/00
Foreign References:
| US4467808A | 1984-08-28 | |||
| US20030211084A1 | 2003-11-13 |
Other References:
WANG W. ET AL: "Up-regulation of Chondrocyte Matrix Genes and Products by Electric Fields.", CLINICAL ORTHOPAEDICS AND REALTED RESEARCH., no. 427S, October 2004 (2004-10-01), pages S163 - S173, XP008051672
BRIGHTON C.T. ET AL: "Signal Transduction in Electrically Stimuleted Bone Cells.", THE JOURNAL OF BONE AND JOINT SURGERY AM., vol. 83-A, no. 10, October 2001 (2001-10-01), pages 1514 - 1523, XP008055319
ZHUANG H. ET AL: "Electrical Stimulation Induces the Level of TGF-b1 mRNA in Osteoblastic Cells by mechanism involving Calcium/Calmodulin Pathway.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS., vol. 237, 1997, pages 225 - 229, XP008051705
PIENKOWSKI D. ET AL: "Low-power electromagnetic stimulation of osteotomized rabbit fibulae.", THE JOURNAL OF BONE AND JOINT SURGERY., vol. 76-A, no. 4, April 1994 (1994-04-01), pages 489 - 501, XP008051709
BRIGHTON C.T. ET AL: "Signal Transduction in Electrically Stimuleted Bone Cells.", THE JOURNAL OF BONE AND JOINT SURGERY AM., vol. 83-A, no. 10, October 2001 (2001-10-01), pages 1514 - 1523, XP008055319
ZHUANG H. ET AL: "Electrical Stimulation Induces the Level of TGF-b1 mRNA in Osteoblastic Cells by mechanism involving Calcium/Calmodulin Pathway.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS., vol. 237, 1997, pages 225 - 229, XP008051705
PIENKOWSKI D. ET AL: "Low-power electromagnetic stimulation of osteotomized rabbit fibulae.", THE JOURNAL OF BONE AND JOINT SURGERY., vol. 76-A, no. 4, April 1994 (1994-04-01), pages 489 - 501, XP008051709
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