Title:
URACIL DERIVATIVE HAVING VIRAL GROWTH INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2023/195529
Kind Code:
A1
Abstract:
The present invention provides: a compound that exhibits a coronavirus 3CL protease inhibitory activity or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing the same. The compound is represented by formula (I) (where: ring A is represented by formula (I-A) (where: X is a single bond or the like; R2 is a substituted or unsubstituted aromatic carbocyclic group or the like; R3c is a substituted or unsubstituted aromatic carbocyclic group or the like; R3 is a substituted or unsubstituted aromatic carbocyclic group or the like; R3a is a hydrogen atom or the like; R3b is a hydrogen atom; R8a is a substituted or unsubstituted aromatic carbocyclic group or the like; and R8b is a hydrogen atom or the like); R1 is a substituted or unsubstituted aromatic heterocyclic group; m is 0 or the like; R5a is each independently a hydrogen atom or the like; R5b is each independently a hydrogen atom or the like; R6 is cyano or the like; and R7a and R7b are each independently a hydrogen atom or the like) or pharmaceutically acceptable salt thereof.
More Like This:
| WO/2003/051868 | LACTAMS AS TACHYKININ ANTAGONISTS |
| WO/2003/053933 | HETEROARYL-SUBSTITUTED AMINOCYCLOHEXANE DERIVATIVES |
| JP2005518365 | 4-Aminoquinoline compound |
Inventors:
SATO JUN (JP)
SHIBAYAMA HIROMITSU (JP)
HIRAI KEIICHIRO (JP)
UNOH YUTO (JP)
UEHARA SHOTA (JP)
YONEZAWA SHUJI (JP)
KURAHASHI KANA (JP)
KOJIMA EIICHI (JP)
SHIBAYAMA HIROMITSU (JP)
HIRAI KEIICHIRO (JP)
UNOH YUTO (JP)
UEHARA SHOTA (JP)
YONEZAWA SHUJI (JP)
KURAHASHI KANA (JP)
KOJIMA EIICHI (JP)
Application Number:
PCT/JP2023/014316
Publication Date:
October 12, 2023
Filing Date:
April 07, 2023
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07D401/04; A61K31/506; A61K31/519; A61K31/5377; A61K31/5383; A61K31/55; A61P31/14; A61P43/00; C07D401/14; C07D403/14; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D471/04; C07D471/10; C07D487/04; C07D487/08; C07D487/10; C07D491/08; C07D491/10; C07D491/107; C07D498/08; C07D498/10; C07D519/00; C12N7/06; C12N9/99; C12Q1/37
Domestic Patent References:
| WO2012020742A1 | 2012-02-16 | |||
| WO2013118855A1 | 2013-08-15 | |||
| WO2021250648A1 | 2021-12-16 |
Foreign References:
| CN113620888A | 2021-11-09 | |||
| CN113666914A | 2021-11-19 | |||
| CN113735838A | 2021-12-03 | |||
| CN113801097A | 2021-12-17 |
Other References:
CAPLAR VESNA, LIDIJA TUMIR, MLADEN ZINIC: "A novel type of rigid macrocycle with bis(3-uracilyl)methane and hexadiyne units. The uracilophane", CROATICA CHEMICA ACTA, HRVATSKO KEMIJSKO DRUSTVO,CROATIAN CHEMICAL SOCIETY, HR, vol. 69, no. 4, 2 December 1996 (1996-12-02), HR , pages 1617 - 1631, XP093097484, ISSN: 0011-1643
Attorney, Agent or Firm:
SUGITA Ken-ichi et al. (JP)
Download PDF: