Title:
UREA COMPOUND CONTAINING 2-HETEROAROMATIC RING SUBSTITUTION, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/020209
Kind Code:
A1
Abstract:
The present invention relates to a urea compound as represented by formula (I) and containing a 2-heteroaromatic ring substitution; and an enantiomer, diastereomer, racemate or mixture thereof, or a pharmaceutically acceptable salt, solvate, metabolite or prodrug thereof. The compound of formula (I) of the present invention has an inhibitory activity on CDK9; and the representative compound has a significant anti-tumor activity on tumor cells with a high expression of CDK9, and has plasma stability and a low clearance rate.
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Inventors:
HU YOUHONG (CN)
CHEN YI (CN)
XIE ZHICHENG (CN)
DING JIAN (CN)
LI XIN (CN)
FANG YANFEN (CN)
SHEN QIANQIAN (CN)
CHEN YI (CN)
XIE ZHICHENG (CN)
DING JIAN (CN)
LI XIN (CN)
FANG YANFEN (CN)
SHEN QIANQIAN (CN)
Application Number:
PCT/CN2022/107742
Publication Date:
February 23, 2023
Filing Date:
July 26, 2022
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07D213/75; A61K31/506; A61P35/00
Domestic Patent References:
| WO2021155006A1 | 2021-08-05 |
Foreign References:
| JP2002220338A | 2002-08-09 | |||
| CN103923066A | 2014-07-16 | |||
| US20070027147A1 | 2007-02-01 |
Other References:
DATABASE RREGISTRY STN; ANONYMOUS : " CN -Urea, N-[4-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]-N'-3-pyridinyl- (CA INDEX NAME) OTHER CA INDEX NAMES: CN -N-[4-(1-Methyl-1H-pyrazol-4-yl)-2-pyridinyl]-N'-3-pyridinylurea MF -C15 H14 N6 O SR -Chemical Catalog Supplier: Abby PharmaTech, LLC M e ", XP093036386
HONMA TERUKI ET AL: "Structure-Based Generation of a New Class of Potent Cdk4 Inhibitors: New de Novo Design Strategy and Library Design", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 44, 1 January 2001 (2001-01-01), US , pages 4615 - 4627, XP002220243, ISSN: 0022-2623, DOI: 10.1021/jm0103256
LIM SKALDIS P, DEVELOPMENT, vol. 140, 2013, pages 3079 - 3093
CHOU J ET AL., CANCER DISCOV., vol. 10, no. 3, 2020, pages 351 - 370
CHEN R ET AL., BLOOD, vol. 113, 2009, pages 4637 - 4645
MACCALLUM DE ET AL., CANCER RES., vol. 65, 2005, pages 5399 - 5407
GREGORY GP ET AL., LEUKEMIA, vol. 29, 2015, pages 1437 - 1441
KRYSTOF V ET AL., CELL CYCLE, vol. 15, 2016, pages 519 - 527
SHUDONG WANGPETER M. FISCHER, TRENDS PHARMACOL. SCI., vol. 29, 2008, pages 302 - 313
HONMA TERUKI ET AL: "Structure-Based Generation of a New Class of Potent Cdk4 Inhibitors: New de Novo Design Strategy and Library Design", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 44, 1 January 2001 (2001-01-01), US , pages 4615 - 4627, XP002220243, ISSN: 0022-2623, DOI: 10.1021/jm0103256
LIM SKALDIS P, DEVELOPMENT, vol. 140, 2013, pages 3079 - 3093
CHOU J ET AL., CANCER DISCOV., vol. 10, no. 3, 2020, pages 351 - 370
CHEN R ET AL., BLOOD, vol. 113, 2009, pages 4637 - 4645
MACCALLUM DE ET AL., CANCER RES., vol. 65, 2005, pages 5399 - 5407
GREGORY GP ET AL., LEUKEMIA, vol. 29, 2015, pages 1437 - 1441
KRYSTOF V ET AL., CELL CYCLE, vol. 15, 2016, pages 519 - 527
SHUDONG WANGPETER M. FISCHER, TRENDS PHARMACOL. SCI., vol. 29, 2008, pages 302 - 313
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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