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Title:
UREA DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/189877
Kind Code:
A1
Abstract:
The present invention provides a urea compound or a pharmacologically acceptable salt thereof that has a formyl peptide receptor like 1 (hereinafter may be abbreviated as FPRL1) agonist effect, a pharmaceutical composition containing the urea compound or the pharmacologically acceptable salt thereof, and a pharmaceutical use thereof. It has been found that a urea derivative represented by the general formula (I) below or a pharmacologically acceptable salt thereof has a superior FPRL1 agonist effect. Compound (I) or a pharmacologically acceptable salt thereof is highly useful for treatment, prevention, or suppression of inflammatory diseases, chronic airway diseases, cancers, septicemia, allergic symptoms, HIV retrovirus infection, circulatory disorders, neuroinflammation, nervous disorders, pains, prion diseases, amyloidosis, immune disorders and the like.

Inventors:
TAKAHASHI HIROYASU (JP)
WATANABE HIROYUKI (JP)
FUJII KIYOSHI (JP)
SHIBASAKI MITSUHITO (JP)
KAWASHIMA MIKAKO (JP)
KAMIYA MEGUMI (JP)
OHATA KOHEI (JP)
Application Number:
JP2016/002559
Publication Date:
December 01, 2016
Filing Date:
May 26, 2016
Export Citation:
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Assignee:
KYORIN SEIYAKU KK (JP)
International Classes:
C07C275/50; A61K31/343; A61K31/353; A61K31/381; A61K31/41; A61K31/415; A61K31/4192; A61K31/42; A61K31/421; A61K31/4245; A61K31/427; A61K31/428; A61K31/433; A61K31/44; A61K31/454; A61K31/513; A61K31/5377; A61K31/5395; A61P25/00; A61P29/00; A61P31/18; A61P35/00; A61P37/00; C07D213/61; C07D231/12; C07D239/36; C07D249/04; C07D249/08; C07D249/12; C07D257/04; C07D261/08; C07D263/32; C07D263/34; C07D271/06; C07D271/07; C07D271/10; C07D271/113; C07D273/04; C07D277/28; C07D285/08; C07D285/12; C07D285/135; C07D307/79; C07D311/58; C07D333/16; C07D333/28; C07D413/04; C07D413/12; C07D417/12
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Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (Umeda Hankyu Bldg. Office Tower 8-1, Kakuda-cho, Kita-ku, Osaka-sh, Osaka 17, JP)
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