URETHANE MEDIATED, GST SPECIFIC MOLECULAR RELEASE SYSTEMS

Title:

URETHANE MEDIATED, GST SPECIFIC MOLECULAR RELEASE SYSTEMS

Document Type and Number:

WIPO Patent Application WO1996040739

Kind Code:

A3

Abstract:

Compounds of the formula or of the formula or the amides, esters or salts thereof, wherein: Sx is S=O, O=S=O, S=NH, HN=S=O, Se=O, O=Se=O, Se=NH, HN=Se=O, S+R3 wherein R3 is alkyl (1-6C) or O-C=O or HN-C=O; each R of R1, and R2 is independently H or a noninterfering substituent; wherein (conj) represents a conjugated system capable of transmitting electrons; n is 0 or 1; YCO is selected from the group consisting of gamma -Glu, gamma -Glu-Gly, Glu, Glu-Gly, beta Asp, beta -Asp-Gly, Asp and Asp-Gly; AAC is an amino acid linked through a peptide bond to the remainder of said compound of Formula 1; and N(Z) represents a reduced nitrogen-containing leaving group and L represents an electron-withdrawing leaving group, are useful as prodrugs and to generate active components released by the activity of glutathione S-transferase.

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Inventors:

KAUVAR LAWRENCE M
LYTTLE MATTHEW H
SATYAM APPARAO

Application Number:

PCT/US1996/009831

Publication Date:

January 30, 1997

Filing Date:

June 07, 1996

Export Citation:

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Assignee:

TERRAPIN TECH INC (US)

International Classes:

A61K38/04; A61P35/00; A61K38/00; C07K5/02; C07K5/023; C07K5/037; (IPC1-7): C07K5/037; A61K38/04

Domestic Patent References:

WO1995009866A1

1995-04-13

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