Title:
UROKINASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2001096286
Kind Code:
A3
Abstract:
The invention relates to a highly active, highly specific urokinase inhibitor which is suitable for therapeutic applications and can be synthesized in an extremely simple manner. Surprisingly, it was found that amidino benzylamine derivatives, especially 4-amidino-benzylamine, with two bonded amino acids represent a new group of highly active and very selective uPA inhibitors The urokinase ihibitors can be used in medical applications, e;g. in the treatment of malign tumours such as in cases of metastatic spread.
Inventors:
STUERZEBECHER JOERG (DE)
STEINMETZER TORSTEN (DE)
KUENZEL SEBASTIAN (DE)
SCHWEINITZ ANDREA (DE)
STEINMETZER TORSTEN (DE)
KUENZEL SEBASTIAN (DE)
SCHWEINITZ ANDREA (DE)
Application Number:
PCT/EP2001/006789
Publication Date:
June 27, 2002
Filing Date:
June 15, 2001
Export Citation:
Assignee:
UNIV SCHILLER JENA (DE)
STUERZEBECHER JOERG (DE)
STEINMETZER TORSTEN (DE)
KUENZEL SEBASTIAN (DE)
SCHWEINITZ ANDREA (DE)
STUERZEBECHER JOERG (DE)
STEINMETZER TORSTEN (DE)
KUENZEL SEBASTIAN (DE)
SCHWEINITZ ANDREA (DE)
International Classes:
A61K9/02; A61K9/08; A61K9/16; A61K9/20; A61K9/28; C12N9/99; A61K9/48; A61K9/70; A61K31/18; A61K38/00; A61K38/05; A61P35/00; A61P43/00; C07C281/06; C07K5/06; C07K5/062; G01N33/68; (IPC1-7): C07K5/062; C07C281/06; A61K38/05; A61P35/00; G01N33/68
Domestic Patent References:
| WO2000005245A2 | 2000-02-03 |
Foreign References:
| US5863929A | 1999-01-26 | |||
| DE4243858A1 | 1994-06-30 |
Other References:
STÜRZEBECHER J ET AL.: "3-Amidinophenylalanine-based Inhibitors of Urokinase", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, 1999, pages 3147 - 3152, XP002193206
KÜNZEL S ET AL.: "4-Amidinobenzylamine-Based Inhibitors of Urokinase", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, 2002, pages 645 - 648, XP002193207
KÜNZEL S ET AL.: "4-Amidinobenzylamine-Based Inhibitors of Urokinase", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, 2002, pages 645 - 648, XP002193207
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