Title:
UROKINASE PRODUCTION INHIBITORS, ANGIOGENESIS INHIBITORS AND METHODS OF PREVENTION OR TREATMENT WITH BOTH
Document Type and Number:
WIPO Patent Application WO/2000/006154
Kind Code:
A1
Abstract:
Urokinase production inhibitors and angiogenesis inhibitors, characterized by containing as the active ingredient ozonide derivatives represented by general formula (1) and methods of prevention or treatment with both, wherein A is oxygen or N-R (wherein R is phenyl which is optionally substituted with C¿1?-C¿6? lower alkyl, C¿1?-C¿6? lower alkoxy or halogeno); and B is oxo or -R?4¿, with provisos that (1) when A is oxygen, then R?1¿ is hydrogen or the like; R?2¿ is phenyl or the like; R?3¿ is hydrogen or the like; B is oxo or -R?4¿; R?4¿ is hydrogen or the like; and R?5¿ is hydrogen or the like; and (2) when A is N-R, then R?1¿ is hydrogen or the like; R?2¿ is hydrogen or the like; R?3¿ is hydrogen or the like; B is -R?4¿; R?4¿ is hydrogen or the like; and R?5¿ is hydrogen or the like.
More Like This:
| JPS63196515 | COCCIDIOCIDAL COMPOSITION |
| WO/2005/115170 | ORAL AND /OR TOPICAL COMPOSITIONS |
Inventors:
SASAKI TAKUMA (JP)
NOJIMA MASATOMO (JP)
NOJIMA MASATOMO (JP)
Application Number:
PCT/JP1999/004030
Publication Date:
February 10, 2000
Filing Date:
July 28, 1999
Export Citation:
Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
SASAKI TAKUMA (JP)
NOJIMA MASATOMO (JP)
SASAKI TAKUMA (JP)
NOJIMA MASATOMO (JP)
International Classes:
A61K31/35; A61K31/41; C07D493/08; C07D498/08; (IPC1-7): A61K31/35; A61K31/41; C07D493/08; C07D498/08
Foreign References:
| JPS63122687A | 1988-05-26 |
Other References:
SUGIMOTO TOSHIYA ET AL: "Ozonolyses of 1,2-diphenyl- and 2-phenylindene", J. ORG. CHEM., vol. 58, no. 1, 1993, pages 135 - 141, XP002925185
SUGIMOTO TOSHIYA ET AL: "Synthesis of 1,4,2-dioxazolidines by the reaction of keto aldehydes with N-phenylhydroxylamine. Intramolecular(3+2)cycloaddition between the nitrone and carbonyl moieties", J. ORG. CHEM., vol. 55, no. 13, 1990, pages 4221 - 4222, XP002925186
SUGIMOTO TOSHIYA ET AL: "Synthesis of 1,4,2-dioxazolidines by the reaction of keto aldehydes with N-phenylhydroxylamine. Intramolecular(3+2)cycloaddition between the nitrone and carbonyl moieties", J. ORG. CHEM., vol. 55, no. 13, 1990, pages 4221 - 4222, XP002925186
Attorney, Agent or Firm:
Tamura, Iwao (Terauchi 1-chome Toyonaka-shi Osaka, JP)
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