Title:
USE OF 2-CHLORO-N,N-DIETHYLETHYLAMINE HYDROCHLORIDE FOR IMPROVING ANTI-CANCER TREATMENT
Document Type and Number:
WIPO Patent Application WO/2023/059148
Kind Code:
A1
Abstract:
The present invention relates to use of 2-chloro-N,N-diethylethylamine hydrochloride for improving anti-cancer treatment, and has the benefits of killing cancer cells by alkylating a DNA base using a nitrogen mustard-based compound of chemical formula 1, and exhibiting a synergistic effect when used in combination with existing PARP inhibitors.
Inventors:
MYUNG KYUNGJAE (KR)
WIE MINWOO (KR)
GROEHLER IV ARNOLD SCOTT (KR)
SCHARER ORLANDO (KR)
KIM KEONWOO (KR)
CHOI JANGHYUN (KR)
WIE MINWOO (KR)
GROEHLER IV ARNOLD SCOTT (KR)
SCHARER ORLANDO (KR)
KIM KEONWOO (KR)
CHOI JANGHYUN (KR)
Application Number:
PCT/KR2022/015184
Publication Date:
April 13, 2023
Filing Date:
October 07, 2022
Export Citation:
Assignee:
INST BASIC SCIENCE (KR)
ULSAN NAT INST SCIENCE & TECH UNIST (KR)
ULSAN NAT INST SCIENCE & TECH UNIST (KR)
International Classes:
A61K31/131; A61K45/06; A61P35/00
Foreign References:
| JP2021525284A | 2021-09-24 | |||
| KR20210006945A | 2021-01-19 | |||
| KR20200131251A | 2020-11-23 |
Other References:
HASHIMOTO YOSHIYUKI, SUDO HISAYO, ISHIDATE MORIZO: " Inhibitory effect of carcinostatic agents on antitumor activity of sensitized lymphoid cells", JAPANESE JOURNAL OF CANCER RESEARCH - GANN, vol. 5877118853, no. 615, 1 February 1967 (1967-02-01), pages 31 - 44, XP093056661
SAKURAI YOSIO, HIROSHI IMAMURA, AYAKO MORIWAKI: " The Effect of Anti-tumor Agents on the Dehydrogenase Activity of Tumors", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 6, no. 5, 1 January 1958 (1958-01-01), pages 501 - 504, XP093056663
SAKURAI YOSIO, HIROSHI IMAMURA, AYAKO MORIWAKI: " The Effect of Anti-tumor Agents on the Dehydrogenase Activity of Tumors", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 6, no. 5, 1 January 1958 (1958-01-01), pages 501 - 504, XP093056663
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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