Title:
USE OF 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONE IN ANTIVIRAL
Document Type and Number:
WIPO Patent Application WO/2022/012624
Kind Code:
A1
Abstract:
The present invention relates to the use of 2,4,5-trisubstituted 1,2,4-triazolone in an antiviral, and specifically to the use of the compound of formula I in the preparation of a drug, wherein the drug is used for preventing and/or treating diseases associated with viruses. In vitro experiments show that the compound can efficiently inhibit infections of multiple viruses, and same exhibits a lower cytotoxicity in some tests.
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Inventors:
ZHONG WU (CN)
ZHOU XINBO (CN)
CAO RUIYUAN (CN)
XIAO DIAN (CN)
WANG MANLI (CN)
FAN SHIYONG (CN)
HU ZHIHONG (CN)
LI SONG (CN)
ZHOU XINBO (CN)
CAO RUIYUAN (CN)
XIAO DIAN (CN)
WANG MANLI (CN)
FAN SHIYONG (CN)
HU ZHIHONG (CN)
LI SONG (CN)
Application Number:
PCT/CN2021/106486
Publication Date:
January 20, 2022
Filing Date:
July 15, 2021
Export Citation:
Assignee:
ACAD OF MILITARY MEDICAL SCIENCES (CN)
International Classes:
A61K31/4196; A61P31/14; A61P31/16
Foreign References:
| CN111773214A | 2020-10-16 | |||
| CN110023302A | 2019-07-16 | |||
| CN202010692337A | 2020-07-17 |
Other References:
STEGMANN KIM M., DICKMANNS ANTJE, HEINEN NATALIE, GROSS UWE, GÖRLICH DIRK, PFAENDER STEPHANIE, DOBBELSTEIN MATTHIAS: "N4-hydroxycytidine and inhibitors of dihydroorotate dehydrogenase synergistically suppress SARS-CoV-2 replication", BIORXIV, 28 June 2021 (2021-06-28), XP055863440, Retrieved from the Internet [retrieved on 20211119], DOI: 10.1101/2021.06.28.450163
RUI XIONG, ZHANG LEIKE, LI SHILIANG, SUN YUAN, DING MINYI, WANG YONG, ZHAO YONGLIANG, WU YAN, SHANG WEIJUAN, JIANG XIAMING, SHAN J: "Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2", BIORXIV, 12 March 2020 (2020-03-12), XP055740305, Retrieved from the Internet [retrieved on 20201015], DOI: 10.1101/2020.03.11.983056
ANONYMOUS: "East China University of Science and Technology and Wuhan University Have Jointly Discovered An Effective Anti-COVID-19 Drug Candidate and A Drug Currently Used", SHANGHAI CHEMICAL INDUSTRY, vol. 45, no. 2, 30 April 2020 (2020-04-30), pages 76 - 76, XP055886975
G. W. H. CHEESEMANE. S. G. WERSTIUK: "Advances in Heterocyclic Chemistry", vol. 22, CHINESE ACADEMY OF SCIENCES, pages: 390 - 392
RUI XIONG, ZHANG LEIKE, LI SHILIANG, SUN YUAN, DING MINYI, WANG YONG, ZHAO YONGLIANG, WU YAN, SHANG WEIJUAN, JIANG XIAMING, SHAN J: "Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2", BIORXIV, 12 March 2020 (2020-03-12), XP055740305, Retrieved from the Internet
ANONYMOUS: "East China University of Science and Technology and Wuhan University Have Jointly Discovered An Effective Anti-COVID-19 Drug Candidate and A Drug Currently Used", SHANGHAI CHEMICAL INDUSTRY, vol. 45, no. 2, 30 April 2020 (2020-04-30), pages 76 - 76, XP055886975
G. W. H. CHEESEMANE. S. G. WERSTIUK: "Advances in Heterocyclic Chemistry", vol. 22, CHINESE ACADEMY OF SCIENCES, pages: 390 - 392
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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