Title:
USE OF 5-NITRO-8-HYDROXYQUINOLINE
Document Type and Number:
WIPO Patent Application WO/2022/253159
Kind Code:
A1
Abstract:
A use of 5-nitro-8-hydroxyquinoline is provided. Specifically provided is the use of 5-nitro-8-hydroxyquinoline, a pharmaceutically acceptable salt thereof, a crystal form thereof, a solvate thereof, an isotope derivative thereof or a prodrug thereof in preparing an antiviral drug. The 5-nitro-8-hydroxyquinoline, the pharmaceutically acceptable salt thereof, the crystal form thereof, the solvate thereof, the isotope derivative thereof, or the prodrug thereof has significant activity in combatting human papillovirus.
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Inventors:
DENG YIJUN (CN)
Application Number:
PCT/CN2022/095861
Publication Date:
December 08, 2022
Filing Date:
May 30, 2022
Export Citation:
Assignee:
JIANGSU YAHONG MEDITECH CO LTD (CN)
ASIERIS PHARMACEUTICALS SHANGHAI CO LTD (CN)
ASIERIS PHARMACEUTICALS SHANGHAI CO LTD (CN)
International Classes:
A61K31/47; A61L2/16; A61P31/20
Domestic Patent References:
| WO2021023231A1 | 2021-02-11 | |||
| WO2020063824A1 | 2020-04-02 | |||
| WO2020063824A1 | 2020-04-02 | |||
| WO2021238978A1 | 2021-12-02 |
Foreign References:
| CN111773193A | 2020-10-16 | |||
| CN111514142A | 2020-08-11 | |||
| CN103588660A | 2014-02-19 | |||
| CN202110601777A | 2021-05-31 |
Other References:
ROHDE, W. ET AL.: "Hydroxyquinolines inhibit ribonucleic acid-dependent deoxyribonucleic acid polymerase and inactivate Rous sarcoma virus and herpes simplex virus", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 10, no. 2, 31 August 1976 (1976-08-31), XP008050819, ISSN: 0066-4804
FREIREICH ET AL., CANCER CHEMOTHER REP, vol. 50, no. 4008-48-4, 1966, pages 219
"NCBI", Database accession no. HE611260.1
BEADLE, J. ET AL.: "Synthesis and Antiviral Evaluation of Octadecyloxyethyl Benzyl 9-[(2-Phosphonomethoxy) ethyl] guanine (ODE-Bn-PMEG), a Potent Inhibitor of Transient HPV DNA Amplification", J MED CHEM., vol. 59, no. 23, 2016, pages 10470 - 8, XP055717136, DOI: 10.1021/acs.jmedchem.6b00659
KACHAEVA, M. ET AL.: "In vitro activity of novel 1,3-oxazole derivatives against HPV", IBNOSINA J MED BIOMED SCI, vol. 9, no. 4, 2017, pages 111 - 8
FREIREICH ET AL., CANCER CHEMOTHER REP, vol. 50, no. 4008-48-4, 1966, pages 219
"NCBI", Database accession no. HE611260.1
BEADLE, J. ET AL.: "Synthesis and Antiviral Evaluation of Octadecyloxyethyl Benzyl 9-[(2-Phosphonomethoxy) ethyl] guanine (ODE-Bn-PMEG), a Potent Inhibitor of Transient HPV DNA Amplification", J MED CHEM., vol. 59, no. 23, 2016, pages 10470 - 8, XP055717136, DOI: 10.1021/acs.jmedchem.6b00659
KACHAEVA, M. ET AL.: "In vitro activity of novel 1,3-oxazole derivatives against HPV", IBNOSINA J MED BIOMED SCI, vol. 9, no. 4, 2017, pages 111 - 8
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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