Title:
USE OF 6-PHOSPHOGLUCONIC ACID AND DERIVATIVE THEREOF IN PREPARING MEDICAMENT FOR PREVENTING OR TREATING GLYCOMETABOLISM DISORDER DISEASES
Document Type and Number:
WIPO Patent Application WO/2024/055810
Kind Code:
A1
Abstract:
Use of 6-phosphogluconic acid and a derivative thereof in preparing a medicament for preventing or treating glycometabolism disorder diseases. The 6-phosphogluconic acid and the derivative thereof are a type of cell glycometabolism regulators and diabetes treatment agents, have a remarkable regulation effect on islet alpha cells, and can be further prepared into a medicament for preventing or treating diabetes and other glycometabolism disorder diseases.
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Inventors:
ZHOU LU (CN)
LI JIN (CN)
HUANG HE (CN)
XIE WENHAO (CN)
ZHANG YUFENG (CN)
GAO WEI (CN)
LI JIN (CN)
HUANG HE (CN)
XIE WENHAO (CN)
ZHANG YUFENG (CN)
GAO WEI (CN)
Application Number:
PCT/CN2023/113692
Publication Date:
March 21, 2024
Filing Date:
August 18, 2023
Export Citation:
Assignee:
UNIV FUDAN (CN)
International Classes:
A61K31/661; A61K31/6615; A61K31/664; A61K31/675; A61K31/683; A61P1/16; A61P3/00; A61P3/04; A61P3/10; A61P9/10; A61P25/16; A61P25/28; A61P35/00; C07F9/09; C07F9/12; C07F9/24; C07F9/6533
Domestic Patent References:
| WO2016044756A1 | 2016-03-24 | |||
| WO2012029722A1 | 2012-03-08 | |||
| WO2020105562A1 | 2020-05-28 |
Foreign References:
| CN115364110A | 2022-11-22 | |||
| JPH08245397A | 1996-09-24 |
Other References:
GALLARDO-PÉREZ JUAN CARLOS; RIVERO-SEGURA NADIA ALEJANDRA; MARÍN-HERNÁNDEZ ALVARO; MORENO-SÁNCHEZ RAFAEL; RODRÍGUEZ-ENRÍQUEZ SARA : "GPI/AMF inhibition blocks the development of the metastatic phenotype of mature multi-cellular tumor spheroids", BIOCHIMICA ET BIOPHYSICA ACTA, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, vol. 1843, no. 6, 16 January 2014 (2014-01-16), NL , pages 1043 - 1053, XP028844056, ISSN: 0167-4889, DOI: 10.1016/j.bbamcr.2014.01.013
MILEWSKI, S. ; JANIAK, A. ; WOJCIECHOWSKI, M.: "Structural analogues of reactive intermediates as inhibitors of glucosamine-6-phosphate synthase and phosphoglucose isomerase", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ACADEMIC PRESS, US, vol. 450, no. 1, 1 June 2006 (2006-06-01), US , pages 39 - 49, XP024943139, ISSN: 0003-9861, DOI: 10.1016/j.abb.2006.03.019
PALOMINO-SCHÄTZLEIN MARTINA, LAMAS-DOMINGO RUBÉN, CIUDIN ANDREEA, GUTIÉRREZ-CARCEDO PATRICIA, MARÉS ROSÓ, APARICIO-GÓMEZ CAROLINA,: "A Translational In Vivo and In Vitro Metabolomic Study Reveals Altered Metabolic Pathways in Red Blood Cells of Type 2 Diabetes", JOURNAL OF CLINICAL MEDICINE, MULTIDISCIPLINARY DIGITAL PUBLISHING INSTITUTE (MDPI), CH, vol. 9, no. 6, 27 May 2020 (2020-05-27), CH , pages 1619, XP093146137, ISSN: 2077-0383, DOI: 10.3390/jcm9061619
MILEWSKI, S. ; JANIAK, A. ; WOJCIECHOWSKI, M.: "Structural analogues of reactive intermediates as inhibitors of glucosamine-6-phosphate synthase and phosphoglucose isomerase", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ACADEMIC PRESS, US, vol. 450, no. 1, 1 June 2006 (2006-06-01), US , pages 39 - 49, XP024943139, ISSN: 0003-9861, DOI: 10.1016/j.abb.2006.03.019
PALOMINO-SCHÄTZLEIN MARTINA, LAMAS-DOMINGO RUBÉN, CIUDIN ANDREEA, GUTIÉRREZ-CARCEDO PATRICIA, MARÉS ROSÓ, APARICIO-GÓMEZ CAROLINA,: "A Translational In Vivo and In Vitro Metabolomic Study Reveals Altered Metabolic Pathways in Red Blood Cells of Type 2 Diabetes", JOURNAL OF CLINICAL MEDICINE, MULTIDISCIPLINARY DIGITAL PUBLISHING INSTITUTE (MDPI), CH, vol. 9, no. 6, 27 May 2020 (2020-05-27), CH , pages 1619, XP093146137, ISSN: 2077-0383, DOI: 10.3390/jcm9061619
Attorney, Agent or Firm:
SHANGHAI WINSUN INTELLECTUAL PROPERTY AGENCY (CN)
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