Title:
USE OF AN ACTIVE SUBSTANCE THAT BINDS TO CD28 FOR PRODUCING A PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO2003078468
Kind Code:
A3
Abstract:
The invention relates to the use of a superagonistic CD28-specific monoclonal antibody (mAb) or a mimic compound of the same, for producing a pharmaceutical composition for the induction and/or reproduction of regulatory T-cells.
Inventors:
HUENIG THOMAS (DE)
Application Number:
PCT/DE2003/000890
Publication Date:
February 12, 2004
Filing Date:
March 13, 2003
Export Citation:
Assignee:
TEGENERO AG (DE)
HUENIG THOMAS (DE)
HUENIG THOMAS (DE)
International Classes:
C07K16/28; A61K39/00; (IPC1-7): C07K16/28; A61K38/00
Domestic Patent References:
| WO1998030232A1 | 1998-07-16 | |||
| WO2003048194A2 | 2003-06-12 |
Other References:
TACKE M ET AL: "CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor", EUROPEAN JOURNAL OF IMMUNOLOGY, WEINHEIM, DE, vol. 27, no. 1, 1997, pages 239 - 247, XP002090176, ISSN: 0014-2980
JUNG S ET AL: "PREVENTION AND THERAPY OF EXPERIMENTAL AUTOIMMUNE NEURITIS BY AN ANTIBODY AGAINST T CELL RECEPTORS-ALPHA-BETA", JOURNAL OF IMMUNOLOGY, vol. 148, no. 12, 1992, pages 3768 - 3775, XP002261823, ISSN: 0022-1767
MALOY KEVIN J ET AL: "Regulatory T cells in the control of immune pathology.", NATURE IMMUNOLOGY, vol. 2, no. 9, September 2001 (2001-09-01), pages 816 - 822, XP002261824, ISSN: 1529-2908 (ISSN print)
LIN CHIA-HUEY ET AL: "Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist.", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 33, no. 3, March 2003 (2003-03-01), pages 626 - 638, XP001156306, ISSN: 0014-2980 (ISSN print)
SCHMIDT JENS ET AL: "Treatment and prevention of experimental autoimmune neuritis with superagonistic CD28-specific monoclonal antibodies.", JOURNAL OF NEUROIMMUNOLOGY, vol. 140, no. 1-2, July 2003 (2003-07-01), pages 143 - 152, XP002261826, ISSN: 0165-5728 (ISSN print)
LÜHDER FRED ET AL: "Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists.", THE JOURNAL OF EXPERIMENTAL MEDICINE. UNITED STATES 21 APR 2003, vol. 197, no. 8, 21 April 2003 (2003-04-21), pages 955 - 966, XP002261827, ISSN: 0022-1007
JUNG S ET AL: "PREVENTION AND THERAPY OF EXPERIMENTAL AUTOIMMUNE NEURITIS BY AN ANTIBODY AGAINST T CELL RECEPTORS-ALPHA-BETA", JOURNAL OF IMMUNOLOGY, vol. 148, no. 12, 1992, pages 3768 - 3775, XP002261823, ISSN: 0022-1767
MALOY KEVIN J ET AL: "Regulatory T cells in the control of immune pathology.", NATURE IMMUNOLOGY, vol. 2, no. 9, September 2001 (2001-09-01), pages 816 - 822, XP002261824, ISSN: 1529-2908 (ISSN print)
LIN CHIA-HUEY ET AL: "Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist.", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 33, no. 3, March 2003 (2003-03-01), pages 626 - 638, XP001156306, ISSN: 0014-2980 (ISSN print)
SCHMIDT JENS ET AL: "Treatment and prevention of experimental autoimmune neuritis with superagonistic CD28-specific monoclonal antibodies.", JOURNAL OF NEUROIMMUNOLOGY, vol. 140, no. 1-2, July 2003 (2003-07-01), pages 143 - 152, XP002261826, ISSN: 0165-5728 (ISSN print)
LÜHDER FRED ET AL: "Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists.", THE JOURNAL OF EXPERIMENTAL MEDICINE. UNITED STATES 21 APR 2003, vol. 197, no. 8, 21 April 2003 (2003-04-21), pages 955 - 966, XP002261827, ISSN: 0022-1007
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