Title:
USE OF ADNF POLYPEPTIDES FOR TREATING ANXIETY AND DEPRESSION
Document Type and Number:
WIPO Patent Application WO2004080957
Kind Code:
A3
Abstract:
This invention relates to the use of ADNF polypeptides in the treatment of anxiety and/or depression. The present invention also relates to drug discovery assays using the ADNF polypeptide mechanism of action and target interaction, as well as the manufacture of medicaments, methods of application and fomulation therefor. Embodiments of the invention provide methods for preventing and/or treating anxiety and depression disorders in a subject by administering a NAP, an 8-amino-acid peptide derived from Activity Dependent Neurotrophic Factor (ADNF III), in an amount sufficient to improve postnatal performace. The ADNF ploypeptides include ADNF I and ADNF III (also referred to as ADNP) polypeptides, analogs, subsequences, and D-amino acid versions (either wholly D-amino acid peptides or mixed D- and L-amino acid peptides), and combinations thereof which contain their respective active core sites and provide neuroprotective and anti-anxiety functions.
Inventors:
GOZES ILLANA (IL)
ALCALAY ROY N (IL)
DIVINSKI INNA (IL)
GILADI ELIEZER (IL)
ALCALAY ROY N (IL)
DIVINSKI INNA (IL)
GILADI ELIEZER (IL)
Application Number:
PCT/IL2004/000232
Publication Date:
April 14, 2005
Filing Date:
March 11, 2004
Export Citation:
Assignee:
UNIV RAMOT (IL)
GOZES ILLANA (IL)
ALCALAY ROY N (IL)
DIVINSKI INNA (IL)
GILADI ELIEZER (IL)
GOZES ILLANA (IL)
ALCALAY ROY N (IL)
DIVINSKI INNA (IL)
GILADI ELIEZER (IL)
International Classes:
A61K38/00; A61K38/03; C07D; (IPC1-7): A61K38/00
Domestic Patent References:
| WO2000053217A2 | 2000-09-14 | |||
| WO2000027875A2 | 2000-05-18 |
Foreign References:
| US6613740B1 | 2003-09-02 |
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