Title:
USE OF AGENT DEACETYLATING KLF4 TO PROMOTE TRANSCRIPTIONAL ACTIVITY THEREOF, METHOD FOR MAINTAINING FUNCTIONS OF PULMONARY ARTERY ENDOTHELIAL CELLS, AND METHOD FOR TREATING PULMONARY ARTERIAL HYPERTENSION
Document Type and Number:
WIPO Patent Application WO/2023/159601
Kind Code:
A1
Abstract:
USE of an agent that deacetylates a transcription factor KLF4 to promote a transcriptional activity thereof in preparation of a medicament for treating pulmonary arterial hypertension is provided. The agent is configured to deacetylate the KLF4 at a K228. A method for maintaining functions of pulmonary artery endothelial cells in vitro by deacetylating a transcription factor KLF4 to promote a transcriptional activity thereof, includes: contacting pulmonary artery endothelial cells with an agent in an amount effective to increase the deacetylation of KLF4. The agent is configured to deacetylate the KLF4 at a K228 to promote the transcriptional activity thereof towards Pdgfb. A method for treating pulmonary arterial hypertension, includes: administering an effective amount of an agent that deacetylates a transcription factor KLF4 to promote a transcriptional activity thereof to a patient or a subject in need of treatment. The agent is configured to deacetylate the KLF4 at a K228.
Inventors:
LIU BAOHUA (CN)
ZHANG JIN (CN)
ZHANG JIN (CN)
Application Number:
PCT/CN2022/078408
Publication Date:
August 31, 2023
Filing Date:
February 28, 2022
Export Citation:
Assignee:
UNIV SHENZHEN (CN)
International Classes:
A61K48/00; A61P9/12; C12N15/113; C12N15/86
Domestic Patent References:
| WO2021141955A1 | 2021-07-15 | |||
| WO2018041959A1 | 2018-03-08 |
Foreign References:
| CN103391777A | 2013-11-13 | |||
| CN109701033A | 2019-05-03 |
Other References:
SHI LEI; TANG XIAOLONG; QIAN MINXIAN; LIU ZUOJUN; MENG FANBIAO; FU LI; WANG ZIMEI; ZHU WEI-GUO; HUANG JIAN-DONG; ZHOU ZHONGJUN; LI: "A SIRT1-centered circuitry regulates breast cancer stemness and metastasis", ONCOGENE, NATURE PUBLISHING GROUP UK, LONDON, vol. 37, no. 49, 23 July 2018 (2018-07-23), London , pages 6299 - 6315, XP036653457, ISSN: 0950-9232, DOI: 10.1038/s41388-018-0370-5
LI ZIMING, HUANG JIA, SHEN SHENGPING, DING ZHENPING, LUO QINGQUAN, CHEN ZHIWEI, LU SHUN: "RETRACTED ARTICLE: SIRT6 drives epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer via snail-dependent transrepression of KLF4", JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, vol. 37, no. 1, 22 December 2018 (2018-12-22), pages 323, XP093087634, DOI: 10.1186/s13046-018-0984-z
XINJIAN ZHANG; JUNLIANG CHEN; LINA SUN; YONG XU: "SIRT1 deacetylates KLF4 to activate Claudinâ5 transcription in ovarian cancer cells", JOURNAL OF CELLULAR BIOCHEMISTRY, JOHN WILEY & SONS, INC. JOHN WILEY & SONS, INC., HOBOKEN, USA, vol. 119, no. 2, 17 October 2017 (2017-10-17), Hoboken, USA, pages 2418 - 2426, XP071662024, ISSN: 0730-2312, DOI: 10.1002/jcb.26404
LI ZIMING, HUANG JIA, SHEN SHENGPING, DING ZHENPING, LUO QINGQUAN, CHEN ZHIWEI, LU SHUN: "RETRACTED ARTICLE: SIRT6 drives epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer via snail-dependent transrepression of KLF4", JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, vol. 37, no. 1, 22 December 2018 (2018-12-22), pages 323, XP093087634, DOI: 10.1186/s13046-018-0984-z
XINJIAN ZHANG; JUNLIANG CHEN; LINA SUN; YONG XU: "SIRT1 deacetylates KLF4 to activate Claudinâ5 transcription in ovarian cancer cells", JOURNAL OF CELLULAR BIOCHEMISTRY, JOHN WILEY & SONS, INC. JOHN WILEY & SONS, INC., HOBOKEN, USA, vol. 119, no. 2, 17 October 2017 (2017-10-17), Hoboken, USA, pages 2418 - 2426, XP071662024, ISSN: 0730-2312, DOI: 10.1002/jcb.26404
Attorney, Agent or Firm:
SHENZHEN ZHONGYI UNION INTELLECTUAL PROPERTY AGENCY CO.,LTD. (CN)
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