Title:
USE OF ALBIFLORIN OR PAEONIFLORIN IN THE PREVENTION AND/OR TREATMENT OF RENAL ANEMIA
Document Type and Number:
WIPO Patent Application WO/2021/098826
Kind Code:
A1
Abstract:
Use of albiflorin, paeoniflorin or a composition containing albiflorin or paeoniflorin in the preparation of drugs, healthcare products, food nutritional agents or food additives for increasing endogenous erythropoietin; and use of albiflorin, paeoniflorin or a composition containing albiflorin or paeoniflorin in the preparation of drugs, healthcare products, food nutritional agents or food additives for preventing and/or treating primary anemia, secondary anemia or renal anemia by increasing endogenous erythropoietin. Albiflorin and paeoniflorin are derived from Radix Paeoniae Alba having medicine and food homology, and are naturally occurring single agents. Compared with other compound drugs in the prior art, higher safety and patient compliance are achieved.
Inventors:
ZHANG ZUOGUANG (CN)
TIAN HUI (CN)
TIAN HUI (CN)
Application Number:
PCT/CN2020/130437
Publication Date:
May 27, 2021
Filing Date:
November 20, 2020
Export Citation:
Assignee:
ZHANG ZUOGUANG (CN)
International Classes:
A61P7/06; A61K31/7048
Foreign References:
| CN105377280A | 2016-03-02 | |||
| CN101040864A | 2007-09-26 |
Other References:
ZHANG JIAN-JUN ,HUANG YIN-FENG ,WANG LI-LI ,LI WEI ,WANG JING-XIA ,WANG CHUN , QU SHENG-SHENG: "Comparative Study on Effects of Blood Enriching on Mouse Model of Blood Deficiency Syndrome Induced by Compound Method of Bleeding,Starved Feeding and Exhausting of Paeoniae Radix Alba and Paeoniae Radix Rubra, Paeoniflorin and Albiflorin", CHINA JOURNAL OF CHINESE MATERIA MEDICA, vol. 38, no. 19, 31 October 2013 (2013-10-31), pages 3358 - 3362, XP055813467, DOI: 10.4268/cjcmm20131928
WANG CHENGLONG ,WANG LINYUAN ,WANG JINGXIA ,ZHU YINGLI ,ZHAO DANPING ,ZHANG JIANJUN: "Study of Blood Nourishing Effects of Albiflorin and Paeoniflorin on Blood Deficiency Mouse Model Induced by Irradiation of and Effect on Levels of IL-3, GM-CSF, IL-6 and TNF-alpha ", WORLD CHINESE MEDICINE, vol. 11, no. 8, 5 September 2016 (2016-09-05), pages 1574 - 1577, XP055813475
ZHU YING-LI , ZHANG JIAN-JUN , WANG JING-XIA , YANG ZHI-HUI , HUANG YIN-FENG ,QU SHENG-SHENG ,ZHOU TIAN-TIAN: "Comparative Study on Effects of Blood Enriching on Mouse Model of Blood Deficiency Syndrome Induced by Cyclophosphamide of Albiflorin, Paeoniflorin on Levels of GM-CSF, IL-3 and TNF-alpha ", CHINA JOURNAL OF CHINESE MATERIA MEDICA, vol. 40, no. 2, 15 January 2015 (2015-01-15), pages 330 - 333, XP009515324, ISSN: 1001-5302
GUO PING , WANG JI-FENG , WANG SHENG-QI: "Effects of Paeoniflorin on Epo And G-CSF Gene Expression in Bone Marrow of Irradiated Blood Deficiency Mice", JOURNAL OF SHANDONG UNIVERSITY OF TRADITIONAL CHINESE MEDICINE, vol. 29, no. 3, 15 June 2005 (2005-06-15), pages 236 - 239, XP055813483, DOI: 10.16294/j.cnki.1007-659x.2005.03.026
FENG WEIKE , GUO PING: "Research Progress on Pharmacological Action of Paeoniflorin", SHANDONG JOURNAL OF TRADITIONAL CHINESE MEDICINE, vol. 38, no. 1, 3 January 2019 (2019-01-03), pages 105 - 108, XP055813492, ISSN: 0257-258X, DOI: 10.16295/j.cnki.0257-358x.2019.01.025
ZONG KAI-QI,MA ZENG-CHUN,GAO YUE: "Paeoniflorin Increases Gene Expression of Erythropoietin through Adenosine A1 and A2alpha Receptors in Hypoxia", CHINESE PHARMACOLOGICAL BULLETIN, vol. 24, no. 10, 20 October 2008 (2008-10-20), pages 1280 - 1284, XP055813500
WANG CHENGLONG ,WANG LINYUAN ,WANG JINGXIA ,ZHU YINGLI ,ZHAO DANPING ,ZHANG JIANJUN: "Study of Blood Nourishing Effects of Albiflorin and Paeoniflorin on Blood Deficiency Mouse Model Induced by Irradiation of and Effect on Levels of IL-3, GM-CSF, IL-6 and TNF-alpha ", WORLD CHINESE MEDICINE, vol. 11, no. 8, 5 September 2016 (2016-09-05), pages 1574 - 1577, XP055813475
ZHU YING-LI , ZHANG JIAN-JUN , WANG JING-XIA , YANG ZHI-HUI , HUANG YIN-FENG ,QU SHENG-SHENG ,ZHOU TIAN-TIAN: "Comparative Study on Effects of Blood Enriching on Mouse Model of Blood Deficiency Syndrome Induced by Cyclophosphamide of Albiflorin, Paeoniflorin on Levels of GM-CSF, IL-3 and TNF-alpha ", CHINA JOURNAL OF CHINESE MATERIA MEDICA, vol. 40, no. 2, 15 January 2015 (2015-01-15), pages 330 - 333, XP009515324, ISSN: 1001-5302
GUO PING , WANG JI-FENG , WANG SHENG-QI: "Effects of Paeoniflorin on Epo And G-CSF Gene Expression in Bone Marrow of Irradiated Blood Deficiency Mice", JOURNAL OF SHANDONG UNIVERSITY OF TRADITIONAL CHINESE MEDICINE, vol. 29, no. 3, 15 June 2005 (2005-06-15), pages 236 - 239, XP055813483, DOI: 10.16294/j.cnki.1007-659x.2005.03.026
FENG WEIKE , GUO PING: "Research Progress on Pharmacological Action of Paeoniflorin", SHANDONG JOURNAL OF TRADITIONAL CHINESE MEDICINE, vol. 38, no. 1, 3 January 2019 (2019-01-03), pages 105 - 108, XP055813492, ISSN: 0257-258X, DOI: 10.16295/j.cnki.0257-358x.2019.01.025
ZONG KAI-QI,MA ZENG-CHUN,GAO YUE: "Paeoniflorin Increases Gene Expression of Erythropoietin through Adenosine A1 and A2alpha Receptors in Hypoxia", CHINESE PHARMACOLOGICAL BULLETIN, vol. 24, no. 10, 20 October 2008 (2008-10-20), pages 1280 - 1284, XP055813500
Attorney, Agent or Firm:
PANAWELL & PARTNERS, LLC (CN)
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