Title:
USE OF AMINOTHIAZOLE DERIVATIVE IN PREPARATION OF IMMUNOLOGICAL INFLAMMATORY DRUG
Document Type and Number:
WIPO Patent Application WO/2023/011609
Kind Code:
A1
Abstract:
Provided in the present invention is the use of an aminothiazole derivative in the preparation of an immunological inflammatory drug. The drug of the present invention has obvious effects on superficial immunoinflammatory dermatitis such as psoriasis, neurodermatitis, atopic dermatitis eczema, allergic dermatitis, urticaria, seborrheic dermatitis and alopecia, abnormal scar formation and pathological pigmentation, and is safe and non-toxic. The drug also has effects on surface inflammations such as chronic rhinitis, conjunctivitis, dry eye syndrome, allergic asthma, chronic bronchitis, immunological inflammation caused by various mucosal and epidermal injuries and chronic inflammation of various mucosa and epidermis. The immunological inflammatory diseases also comprise other chronic, refractory, immunoinflammatory diseases such as autoimmune diseases (such as, diabetes and systemic lupus erythematosus), various immunological chronic inflammatory diseases (such as, chronic colitis and allergies), ischemia-reperfusion injury and nervous system chronic inflammation (such as, neurodegenerative diseases, Alzheimer's disease and depression).
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Inventors:
ZHOU PING (CN)
JIANG FENGCHAO (CN)
JIANG FENGCHAO (CN)
Application Number:
PCT/CN2022/110395
Publication Date:
February 09, 2023
Filing Date:
August 04, 2022
Export Citation:
Assignee:
INNAMUNE PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/496; A61K9/06; A61P3/10; A61P17/06; A61P17/08; A61P17/14; A61P25/24; A61P25/28; A61P29/00; A61P37/08
Foreign References:
| CN113730410A | 2021-12-03 | |||
| CN102336720A | 2012-02-01 | |||
| CN101849982A | 2010-10-06 | |||
| CN102166214A | 2011-08-31 |
Other References:
KEYUAN: "The first self-innovated inhibitor targeting the innate immune system made a major breakthrough in scientific research - Bian Shuguang, deputy director of the High Technology Research and Development Center of the Ministry of Science and Technology, visited the Institute of Organ Transplantation, To", MODERN SCIENCE, no. 22, 31 December 2011 (2011-12-31), pages 9 - 12, XP093031343
GUAN XIN-LEI, JIANG FENG-CHAO;WANG YUE;WU PENG-FEI;WANG FANG;CHEN JIAN-GUO: "Pharmacophore Identification of Novel Dual-target Compounds Targeting AChE and PARP-1", ACTA PHARMACEUTICA SINICA, vol. 49, no. 6, 12 June 2014 (2014-06-12), CN , pages 819 - 823, XP093031364, ISSN: 0513-4870, DOI: 10.16438/j.0513-4870.2014.06.020
ZOU ZHIMIAO; DU DUNFENG; MIAO YAN; YANG YANG; XIE YALONG; LI ZEYANG; ZHOU LIANG; ZHANG LIMIN; ZHOU PING; JIANG FENGCHAO: "TJ-M2010-5, a novel MyD88 inhibitor, corrects R848-induced lupus-like immune disorders of B cells in vitro", INTERNATIONAL IMMUNOPHARMACOLOGY, vol. 85, 5 June 2020 (2020-06-05), NL , pages 1 - 10, XP086208842, ISSN: 1567-5769, DOI: 10.1016/j.intimp.2020.106648
PAPADOPOULOU, C. GERONIKAKI, A. HADJIPAVLOU-LITINA, D.: "Synthesis and biological evaluation of new thiazolyl/benzothiazolyl-amides, derivatives of 4-phenyl-piperazine", IL FARMACO, vol. 60, no. 11-12, 1 November 2005 (2005-11-01), FR , pages 969 - 973, XP005151571, ISSN: 0014-827X, DOI: 10.1016/j.farmac.2005.06.014
GUAN XIN-LEI, JIANG FENG-CHAO;WANG YUE;WU PENG-FEI;WANG FANG;CHEN JIAN-GUO: "Pharmacophore Identification of Novel Dual-target Compounds Targeting AChE and PARP-1", ACTA PHARMACEUTICA SINICA, vol. 49, no. 6, 12 June 2014 (2014-06-12), CN , pages 819 - 823, XP093031364, ISSN: 0513-4870, DOI: 10.16438/j.0513-4870.2014.06.020
ZOU ZHIMIAO; DU DUNFENG; MIAO YAN; YANG YANG; XIE YALONG; LI ZEYANG; ZHOU LIANG; ZHANG LIMIN; ZHOU PING; JIANG FENGCHAO: "TJ-M2010-5, a novel MyD88 inhibitor, corrects R848-induced lupus-like immune disorders of B cells in vitro", INTERNATIONAL IMMUNOPHARMACOLOGY, vol. 85, 5 June 2020 (2020-06-05), NL , pages 1 - 10, XP086208842, ISSN: 1567-5769, DOI: 10.1016/j.intimp.2020.106648
PAPADOPOULOU, C. GERONIKAKI, A. HADJIPAVLOU-LITINA, D.: "Synthesis and biological evaluation of new thiazolyl/benzothiazolyl-amides, derivatives of 4-phenyl-piperazine", IL FARMACO, vol. 60, no. 11-12, 1 November 2005 (2005-11-01), FR , pages 969 - 973, XP005151571, ISSN: 0014-827X, DOI: 10.1016/j.farmac.2005.06.014
Attorney, Agent or Firm:
SOON IP LAW FIRM (CN)
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