USE OF ANDROGEN RECEPTOR SUPPRESSORS

Title:

USE OF ANDROGEN RECEPTOR SUPPRESSORS

Document Type and Number:

WIPO Patent Application WO2000037430

Kind Code:

A3

Abstract:

Substituted phenylalanines are provided comprising an hydantoin, urea or 2-hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamido and haloarylamino derivatives thereof, as well as radiolabeled derivatives thereof. The compounds bind specifically to the androgen receptor and find use in indication associated with the androgen receptor, such as cell hyperplasia dependent on androgens, hirsutism, acne and androgenetic alopecia.

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Inventors:

SOVAK MILOS
SELIGSON ALLEN L
DOUGLAS JAMES GORDON III
CAMPION BRIAN
BROWN JASON W

Application Number:

PCT/US1999/026862

Publication Date:

April 17, 2003

Filing Date:

November 12, 1999

Export Citation:

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Assignee:

BIOPHYSICA INC (US)

International Classes:

A61K31/165; A61P5/00; C07C237/04; C07C255/56; C07C255/60; C07C275/30; C07C317/46; C07C323/60; C07C335/08; C07C335/16; C07C335/22; C07D207/408; C07D233/72; C07D233/86; C07D233/88; C07D207/40; (IPC1-7): C07C237/04; A61K31/16; A61K31/40; A61K31/415; C07C237/22; C07C323/60; C07C317/48; C07D207/40; C07D207/26; C07D233/88; C07D233/86; C07C235/22; C07C335/16; C07C335/08; C07C255/56; C07C255/60; C07C275/30; C07D207/36; C07M5/00; A61P5/00

Foreign References:

US5411981A	1995-05-02
US5750553A	1998-05-12

Other References: