Title:
USE OF ANTIGUNAL AGENTS FOR THE TOPIAL TREATMENT OF FUNGUS-INDUCED MUCOSITIS
Document Type and Number:
WIPO Patent Application WO1999020261
Kind Code:
A3
Abstract:
The invention involves methods and materials for treating and preventing non-invasive fungus-induced mucositis. Specifically, the invention involves administrating an antifungal agent such that it contacts mucus in an amount, at a frequency, and for a duration effective to prevent, reduce, or eliminate non-invasive fungus-induced rhinosinusitis. This invention also provides methods and materials for diagnosing non-invasive fungus-induced rhinosinusitis and culturing non-invasive fungus from a mammalian mucus sample as well as specific antifungal formulations and medical devices for treating and preventing non-invasive fungus-induced rhinosinusitis. In addition, the invention provides methods and materials for treating and preventing other non-invasive fungus-induced mucositis conditions such as chronic otitis media, chronic colitis, and Crohn's disease. Further, the invention involves methods and materials for treating and preventing chronic asthma symptoms.
Inventors:
PONIKAU JENS (US)
Application Number:
PCT/US1998/022403
Publication Date:
February 17, 2000
Filing Date:
October 22, 1998
Export Citation:
Assignee:
PONIKAU JENS (US)
International Classes:
A61K9/00; A61K9/06; A61K9/08; C07D249/08; A61K9/10; A61K9/12; A61K9/14; A61K31/00; A61K31/085; A61K31/135; A61K31/137; A61K31/19; A61K31/20; A61K31/201; A61K31/27; A61K31/343; A61K31/4164; A61K31/4174; A61K31/4196; A61K31/44; A61K31/4418; A61K31/443; A61K31/496; A61K31/506; A61K31/513; A61K31/5375; A61K31/70; A61K31/7042; A61K31/7048; A61K39/00; A61K45/00; A61K45/06; A61P11/02; A61P11/06; A61P27/16; A61P31/10; C07D213/89; C07D233/60; C07D233/61; C07D233/62; C07D239/36; C07D307/94; C07D405/06; C07D405/14; C07H17/08; C07K14/37; C12N1/14; (IPC1-7): A61K31/70; A61K31/415; A61K31/505
Domestic Patent References:
| WO1995008993A1 | 1995-04-06 | |||
| WO1997003651A1 | 1997-02-06 |
Foreign References:
| US4883785A | 1989-11-28 |
Other References:
J.P. BENT III: "Antifungal activity against allergic fungal sinusitis organisms", LARYNGOSCOPE, vol. 106, no. 11, 1996, pages 1331 - 1334, XP002106598
A. BASSIOUNY: "Non-invasive antromycosis", J. LARYNGOL. OTOL., vol. 96, no. 3, 1982, pages 215 - 228, XP002106599
I.F. PURCELL: "Use of nebulised liposomal amphotericin B in the treatment of Aspergillus fumigatus empyema", THORAX, vol. 50, no. 12, 1995, pages 1321 - 1323, XP002121854
C.E. CROSS: "Amphotericin B aerosol for transientyl immunocompromised hosts", CHEST, vol. 108, no. 3, 1995, pages 599 - 601, XP002121855
J. VAN CUTSEM: "Oral, topical and parenteral antifungal treatment with itraconazole in normal and immunocompromised animals", MYCOSES, vol. 32, no. suppl. 1, 1989, pages 14 - 34, XP002121856
VON S. NOLTING: "Candida und der Intestinaltrakt", FORTSCHRITTE DER MEDIZIN, vol. 116, no. 5, February 1998 (1998-02-01), pages 22 - 28, XP002121857
H. BAUMJOHANN: "Rezidivierende Vaginal- und Darmmykosen", TW GYNAEKOLOGIE, vol. 4, no. 6, 1991, pages 400 - 402, XP002121858
S. TIWARI: "Chronic bilateral suppurative otitis media caused by Aspergillus terreus", MYCOSES, vol. 38, no. 7-8, 1995, pages 297 - 300, XP002121859
A. BASSIOUNY: "Non-invasive antromycosis", J. LARYNGOL. OTOL., vol. 96, no. 3, 1982, pages 215 - 228, XP002106599
I.F. PURCELL: "Use of nebulised liposomal amphotericin B in the treatment of Aspergillus fumigatus empyema", THORAX, vol. 50, no. 12, 1995, pages 1321 - 1323, XP002121854
C.E. CROSS: "Amphotericin B aerosol for transientyl immunocompromised hosts", CHEST, vol. 108, no. 3, 1995, pages 599 - 601, XP002121855
J. VAN CUTSEM: "Oral, topical and parenteral antifungal treatment with itraconazole in normal and immunocompromised animals", MYCOSES, vol. 32, no. suppl. 1, 1989, pages 14 - 34, XP002121856
VON S. NOLTING: "Candida und der Intestinaltrakt", FORTSCHRITTE DER MEDIZIN, vol. 116, no. 5, February 1998 (1998-02-01), pages 22 - 28, XP002121857
H. BAUMJOHANN: "Rezidivierende Vaginal- und Darmmykosen", TW GYNAEKOLOGIE, vol. 4, no. 6, 1991, pages 400 - 402, XP002121858
S. TIWARI: "Chronic bilateral suppurative otitis media caused by Aspergillus terreus", MYCOSES, vol. 38, no. 7-8, 1995, pages 297 - 300, XP002121859
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