Title:
USE OF ANTROQIONONOL FOR TREATING OBESITY, AND PROCESS FOR PREPARATION OF ANTROQUINONOL
Document Type and Number:
WIPO Patent Application WO/2016/037566
Kind Code:
A1
Abstract:
Provided is the use of antroquinonol for manufacturing a composition or medicament for treating obesity. In addition, new processes for the total synthesis of antroquinonol and new compounds produced during the processes are disclosed.
Inventors:
WENG CHING-FENG (CN)
CHEN CHIN-PIAO (CN)
SHIVAJI SULAKE ROHIDAS (IN)
HUANG ZI-LING (CN)
CHEN CHIN-PIAO (CN)
SHIVAJI SULAKE ROHIDAS (IN)
HUANG ZI-LING (CN)
Application Number:
PCT/CN2015/089224
Publication Date:
March 17, 2016
Filing Date:
September 09, 2015
Export Citation:
Assignee:
WENG CHING-FENG (CN)
International Classes:
C07C45/61; A61K31/12; A61P3/04; C07C49/753
Domestic Patent References:
| WO2014130618A1 | 2014-08-28 | |||
| WO2014081675A1 | 2014-05-30 |
Foreign References:
| US20130203861A1 | 2013-08-08 | |||
| US20150203430A1 | 2015-07-23 | |||
| CN104784161A | 2015-07-22 |
Other References:
WANG SHENGCHAO ET AL.: "Antroquinonol D, Isolated from Antrodia camphorata, with DNA Demethylation and Anticancer Potential", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 62, no. 24, 1 May 2014 (2014-05-01), pages 5625 - 5635
DATABASE REGISTRY 14 October 2002 (2002-10-14), ACS, retrieved from STN Database accession no. 209551-73-5/RN
KOBAYASHI SHOJI ET AL.: "Evaluation of cyclopentyl methyl ether (CPME) as a solvent for radical reactions", TETRAHEDRON, vol. 69, no. 10, 18 January 2013 (2013-01-18), pages 2251 - 2259, XP028969810, DOI: doi:10.1016/j.tet.2013.01.030
SULAKE ROHIDAS S. ET AL.: "Synthesis of (+)-Antroquinonol: An Antihyperglycemic Agent", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 80, no. 12, 3 June 2015 (2015-06-03), pages 6044 - 6051
SULAKE ROHIDAS S. ET AL.: "Total Synthesis of (±)-Antroquinonol D", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 79, no. 22, 6 November 2014 (2014-11-06), pages 10820 - 10828
SULAKE ROHIDAS S. ET AL.: "Total Synthesis of (+)-Antroquinonol and (+)-Antroquinonol D", ORGANIC LETTERS, vol. 17, no. 5, 13 February 2015 (2015-02-13), pages 1138 - 1141
ANA M.GÔMEZ ET AL.: "A Stereodivergent Approach to 5a-Carba-alpha-D-gluco-, -alpha-D- galacto and -beta-L-gulopyranose Pentaacetates from D-Mannose, Based on 6-exo-dig Radical Cyclization and Barton-McCombie Radical Deoxygenation", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2004, no. 08, 29 March 2004 (2004-03-29), pages 1830 - 1840
DATABASE REGISTRY 14 October 2002 (2002-10-14), ACS, retrieved from STN Database accession no. 209551-73-5/RN
KOBAYASHI SHOJI ET AL.: "Evaluation of cyclopentyl methyl ether (CPME) as a solvent for radical reactions", TETRAHEDRON, vol. 69, no. 10, 18 January 2013 (2013-01-18), pages 2251 - 2259, XP028969810, DOI: doi:10.1016/j.tet.2013.01.030
SULAKE ROHIDAS S. ET AL.: "Synthesis of (+)-Antroquinonol: An Antihyperglycemic Agent", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 80, no. 12, 3 June 2015 (2015-06-03), pages 6044 - 6051
SULAKE ROHIDAS S. ET AL.: "Total Synthesis of (±)-Antroquinonol D", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 79, no. 22, 6 November 2014 (2014-11-06), pages 10820 - 10828
SULAKE ROHIDAS S. ET AL.: "Total Synthesis of (+)-Antroquinonol and (+)-Antroquinonol D", ORGANIC LETTERS, vol. 17, no. 5, 13 February 2015 (2015-02-13), pages 1138 - 1141
ANA M.GÔMEZ ET AL.: "A Stereodivergent Approach to 5a-Carba-alpha-D-gluco-, -alpha-D- galacto and -beta-L-gulopyranose Pentaacetates from D-Mannose, Based on 6-exo-dig Radical Cyclization and Barton-McCombie Radical Deoxygenation", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2004, no. 08, 29 March 2004 (2004-03-29), pages 1830 - 1840
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (Tower E3 The Towers, Oriental Plaza, No. 1, East Chang An Avenue,Dongcheng District, Beijing 8, CN)
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