Title:
USE OF B LYMPHOCYTE STIMULATOR PROTEIN ANTAGONISTS TO TREAT ASTHMA AND OTHER ALLERGIC AND INFLAMMATORY CONDITIONS OF THE RESPIRATORY SYSTEM
Document Type and Number:
WIPO Patent Application WO/2011/160086
Kind Code:
A3
Abstract:
Methods of preventing, treating, and ameliorating asthma, allergen-induced respiratory symptoms, and/or an allergic or inflammatory condition of the lung or respiratory system in a patient by administering B Lymphocyte Stimulator antagonists are provided. In addition, a method of reducing total serum IgE levels in a patient suffering from asthma, and/or an allergic or inflammatory condition of the lung or respiratory system by administering B Lymphocyte Stimulator antagonists is provided. A method of treating, preventing or ameliorating an allergen-induced airway hyper responsiveness or increase in mucus-containing cells and/or mucus accumulation or production in the airway epithelium of a patient by administering B Lymphocyte Stimulator antagonist is also provided.
Inventors:
WASSERMAN HEATHER (US)
CARLSON TIMOTHY (US)
MIGONE THI-SAU (US)
DEVALARAJA MADHAV (US)
CARLSON TIMOTHY (US)
MIGONE THI-SAU (US)
DEVALARAJA MADHAV (US)
Application Number:
PCT/US2011/040985
Publication Date:
March 15, 2012
Filing Date:
June 17, 2011
Export Citation:
Assignee:
HUMAN GENOME SCIENCES INC (US)
WASSERMAN HEATHER (US)
CARLSON TIMOTHY (US)
MIGONE THI-SAU (US)
DEVALARAJA MADHAV (US)
WASSERMAN HEATHER (US)
CARLSON TIMOTHY (US)
MIGONE THI-SAU (US)
DEVALARAJA MADHAV (US)
International Classes:
A61K39/395
Foreign References:
| US20050255532A1 | 2005-11-17 |
Other References:
FURIE ET AL.: "Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus.", ARTHRITIS RES THER., vol. 10, no. 5, 2008, pages 1 - 15, XP021046812
SCOTTISH INTERCOLLEGIATE GUIDELINES NETWORK: "British Guideline on the Management of Asthma", BRITISH THORACIC SOCIETY, May 2008 (2008-05-01), pages 1 - 126, XP055073869, Retrieved from the Internet [retrieved on 20120113]
SCOTTISH INTERCOLLEGIATE GUIDELINES NETWORK: "British Guideline on the Management of Asthma", BRITISH THORACIC SOCIETY, May 2008 (2008-05-01), pages 1 - 126, XP055073869, Retrieved from the Internet
Attorney, Agent or Firm:
LEYDIG, VOIT & MAYER, LTD. et al. (180 N. Stetson Ave., Ste. 490, Chicago Illinois, US)
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