Title:
USE OF BILOBALIDE IN PREPARATION OF DRUG FOR PREVENTING OR TREATING DIABETES AND DIABETIC COMPLICATIONS
Document Type and Number:
WIPO Patent Application WO/2024/067576
Kind Code:
A1
Abstract:
Provided in the present invention is the use of bilobalide in the preparation of a drug for preventing or treating diabetes and diabetic complications.
Inventors:
YE FEI (CN)
CHU HONGZHU (CN)
SU GUIZHUAN (CN)
WEI YONGGANG (CN)
GAO ZHIWEN (CN)
SUN YI (CN)
CHU HONGZHU (CN)
SU GUIZHUAN (CN)
WEI YONGGANG (CN)
GAO ZHIWEN (CN)
SUN YI (CN)
Application Number:
PCT/CN2023/121508
Publication Date:
April 04, 2024
Filing Date:
September 26, 2023
Export Citation:
Assignee:
CHENGDU BAIYU PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/365; A61P3/06; A61P3/10
Other References:
MENG ZHAO: "Bilobalide Enhances AMPK Activity to Improve Liver Injury and Metabolic Disorders in STZ-Induced Diabetes in Immature Rats via Regulating HMGB1/TLR4/NF-κB Signaling Pathway", BIOMED RESEARCH INTERNATIONAL, HINDAWI PUBLISHING CORPORATION, vol. 2021, 17 April 2021 (2021-04-17), pages 1 - 11, XP093153864, ISSN: 2314-6133, DOI: 10.1155/2021/8835408
QIANG SU: "Protective Effects of the Bilobalide on Retinal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats", APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, HUMANA PRESS INC, NEW YORK, vol. 194, no. 12, 1 December 2022 (2022-12-01), New York , pages 6407 - 6422, XP093153865, ISSN: 0273-2289, DOI: 10.1007/s12010-022-04012-5
YAN HAO: "Bilobalide alleviates tumor necrosis factor‐alpha‐induced pancreatic beta‐cell MIN6 apoptosis and dysfunction through upregulation of miR‐153", PHYSIOTHERAPY RESEARCH, JOHN WILEY & SONS LTD. CHICHESTER., GB, vol. 34, no. 2, 1 February 2020 (2020-02-01), GB , pages 409 - 417, XP093153872, ISSN: 0951-418X, DOI: 10.1002/ptr.6533
VASSEUR, M. ; JEAN, T. ; DEFEUDIS, F.V. ; DRIEU, K.: "Effects of repeated treatments with an extract of Ginkgo biloba (EGb 761), bilobalide and ginkgolide B on the electrical activity of pancreatic @b cells of normal or alloxan-diabetic mice: An ex vivo study with intracellular microelectrodes", GENERAL PHARMACOLOGY., PERGAMON PRESS, OXFORD., GB, vol. 25, no. 1, 1 January 1994 (1994-01-01), GB , pages 31 - 46, XP025548306, ISSN: 0306-3623, DOI: 10.1016/0306-3623(94)90007-8
YAO, NING ET AL.: "Effect of Bilobalide on Nonalcoholic Fatty Liver Disease Induced by High Fat in Mice", JOURNAL OF HENAN MEDICAL COLLEGE FOR STAFF AND WORKERS, vol. 34, no. 2, 30 April 2022 (2022-04-30)
QIANG SU: "Protective Effects of the Bilobalide on Retinal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats", APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, HUMANA PRESS INC, NEW YORK, vol. 194, no. 12, 1 December 2022 (2022-12-01), New York , pages 6407 - 6422, XP093153865, ISSN: 0273-2289, DOI: 10.1007/s12010-022-04012-5
YAN HAO: "Bilobalide alleviates tumor necrosis factor‐alpha‐induced pancreatic beta‐cell MIN6 apoptosis and dysfunction through upregulation of miR‐153", PHYSIOTHERAPY RESEARCH, JOHN WILEY & SONS LTD. CHICHESTER., GB, vol. 34, no. 2, 1 February 2020 (2020-02-01), GB , pages 409 - 417, XP093153872, ISSN: 0951-418X, DOI: 10.1002/ptr.6533
VASSEUR, M. ; JEAN, T. ; DEFEUDIS, F.V. ; DRIEU, K.: "Effects of repeated treatments with an extract of Ginkgo biloba (EGb 761), bilobalide and ginkgolide B on the electrical activity of pancreatic @b cells of normal or alloxan-diabetic mice: An ex vivo study with intracellular microelectrodes", GENERAL PHARMACOLOGY., PERGAMON PRESS, OXFORD., GB, vol. 25, no. 1, 1 January 1994 (1994-01-01), GB , pages 31 - 46, XP025548306, ISSN: 0306-3623, DOI: 10.1016/0306-3623(94)90007-8
YAO, NING ET AL.: "Effect of Bilobalide on Nonalcoholic Fatty Liver Disease Induced by High Fat in Mice", JOURNAL OF HENAN MEDICAL COLLEGE FOR STAFF AND WORKERS, vol. 34, no. 2, 30 April 2022 (2022-04-30)
Attorney, Agent or Firm:
SINO-CREATIVITY INTELLECTUAL PROPERTY LAW FIRM (CN)
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