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Title:
USE OF CAFFEOL OR DERIVATIVE THEREOF IN PREPARATION OF ANTI-CANDIDA-ALBICANS DRUG OR ANTI-CANDIDA-ALBICANS DAILY ARTICLES
Document Type and Number:
WIPO Patent Application WO/2023/019924
Kind Code:
A1
Abstract:
Provided in the present invention is the use of caffeol or a derivative thereof in the preparation of an anti-Candida-albicans drug or anti-Candida-albicans daily articles. According to the present invention, a compound with high efficiency, low toxicity and not prone to developing drug resistance is selected by taking Candida albicans as a test object. It is found that caffeol or a derivative thereof has a good inhibitory effect on the adhesion, hypha formation, biofilm formation and pathogenicity of Candida albicans. Moreover, kahweol has a good inhibitory effect on the infection of a Candida albicans strain SC5314 on a mouse oral cavity, and the compound itself is not toxic to human cells. Low-concentration kahweol and cafestol have no inhibitory effect on the cell growth of Candida albicans, this indicates that the effect of caffeol or the derivative thereof involves inhibiting the expression of pathogenic factors of Candida albicans instead of relying on killing Candida albicans cells, and thus, drug resistance does not tend to develop.

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Inventors:
DENG YINYUE (CN)
SONG SHIHAO (CN)
WANG GERUN (CN)
TAN HUIHUI (CN)
Application Number:
PCT/CN2022/080168
Publication Date:
February 23, 2023
Filing Date:
March 10, 2022
Export Citation:
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Assignee:
UNIV SUN YAT SEN (CN)
International Classes:
A61K31/343; A61P31/10
Foreign References:
CN113648303A2021-11-16
KR20050107876A2005-11-16
ZA978235B1998-03-03
CN106573063A2017-04-19
Other References:
WANG, WENZHONG: "Coffee and Human Health", FAMILY MEDICINE, 1 September 2020 (2020-09-01), XP093037435, [retrieved on 20230404]
Attorney, Agent or Firm:
GUANGZHOU HUAXUE INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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