Title:
USE OF CASEIN PEPTIDES FOR TREATING HYPERTENSION
Document Type and Number:
WIPO Patent Application WO2004002509
Kind Code:
A3
Abstract:
The invention concerns the use for preparing anti-hypertensive medicines useful for treating or preventing hypertension, of one or more peptides having ACE inhibiting activity with IC50 values not more than 60 mu M, selected among peptide groups having the following amino acid sequences: Thr-Val-Tyr (SEQ ID NO: 1) Asn-Met-Ala-lle-Asn-Pro-Ser-Lys (SEQ ID NO: 2) Phe-Ala-Leu-Pro-Gln-Tyr (SEQ ID NO: 3) Phe-Pro-Gln-Tyr-Leu-Gln-Tyr (SEQ ID NO: 4) Phe-Ala-Leu-Pro-Gln-Tyr-Leu-Lys (SEQ ID NO: 5) Asn-Met-Ala-lle-Asn-Pro (SEQ ID NO: 6) Phe-Ala-Leu-Pro (SEQ ID NO: 7). The invention also concerns a pharmaceutical composition containing, as active principle, an efficient amount of one or more said peptides, in combination with a pharmaceutically acceptable carrier. The invention further concerns a food product, in particular for supplementing the diet of persons liable to hypertension or wishing to prevent its occurrence, containing an efficient amount of one or more said peptides, in combination with food supports, in particular proteins, lipids or carbohydrates. Such a food product may also include at least one of the peptides having the following amino acid sequences: Ala-Leu-Asn-Glu-lle-Asn-Gln-Phe-Tyr-Gln-Lys (SEQ ID NO: 8) Ala-Leu-Asn-Glu-lle-Asn-Gln-Phe-Tyr (SEQ ID NO: 9) Tyr-Leu (SEQ ID NO: 10).
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Inventors:
TAUZIN JEROME (FR)
MICLO LAURENT (FR)
LEFRANC CATHERINE (FR)
BOUDIER JEAN-FRANCOIS (FR)
GAILLARD JEAN-LUC (FR)
MICLO LAURENT (FR)
LEFRANC CATHERINE (FR)
BOUDIER JEAN-FRANCOIS (FR)
GAILLARD JEAN-LUC (FR)
Application Number:
PCT/FR2003/001945
Publication Date:
April 15, 2004
Filing Date:
June 24, 2003
Export Citation:
Assignee:
INGREDIA (FR)
TAUZIN JEROME (FR)
MICLO LAURENT (FR)
LEFRANC CATHERINE (FR)
BOUDIER JEAN-FRANCOIS (FR)
GAILLARD JEAN-LUC (FR)
TAUZIN JEROME (FR)
MICLO LAURENT (FR)
LEFRANC CATHERINE (FR)
BOUDIER JEAN-FRANCOIS (FR)
GAILLARD JEAN-LUC (FR)
International Classes:
A23L1/305; A61K38/05; A61K38/06; A61K38/07; A61K38/08; A61K38/55; A61P9/12; A61P43/00; C07K5/065; C07K5/083; C07K5/107; C07K7/04; C12N9/99; (IPC1-7): A61K38/05; A61K38/06; A61K38/07; A61K38/08; A23L1/305
Foreign References:
| EP0445606A1 | 1991-09-11 | |||
| FR2650955A1 | 1991-02-22 |
Other References:
TAUZIN JEROME ET AL: "Angiotensin-I-converting enzyme inhibitory peptides from tryptic hydrolysate of bovine alphaS2-casein.", FEBS LETTERS, (2002 NOV 6) 531 (2) 369-74., XP004391663
YAMAMOTO ET AL: "Antihypertensive effect of the peptides derived from casein by an extracellular proteinase from Lactobacillus helveticus CP790", JOURNAL OF DAIRY SCIENCE, AMERICAN DAIRY SCIENCE ASSOCIATION. CHAMPAIGN, ILLINOIS, US, vol. 77, no. 4, 1994, pages 917 - 922, XP002095595, ISSN: 0022-0302
YAMAMOTO N ET AL: "PURIFICATION AND CHARACTERIZATION OF AN ANTIHYPERTENSIVE PEPTIDE FROM A YOGURT-LIKE PRODUCT FERMENTED BY LACTOBACILLUS HELVETICUS CPN4", JOURNAL OF DAIRY SCIENCE, AMERICAN DAIRY SCIENCE ASSOCIATION. CHAMPAIGN, ILLINOIS, US, vol. 82, no. 7, July 1999 (1999-07-01), pages 1388 - 1393, XP000850204, ISSN: 0022-0302
YAMAMOTO ET AL: "Antihypertensive effect of the peptides derived from casein by an extracellular proteinase from Lactobacillus helveticus CP790", JOURNAL OF DAIRY SCIENCE, AMERICAN DAIRY SCIENCE ASSOCIATION. CHAMPAIGN, ILLINOIS, US, vol. 77, no. 4, 1994, pages 917 - 922, XP002095595, ISSN: 0022-0302
YAMAMOTO N ET AL: "PURIFICATION AND CHARACTERIZATION OF AN ANTIHYPERTENSIVE PEPTIDE FROM A YOGURT-LIKE PRODUCT FERMENTED BY LACTOBACILLUS HELVETICUS CPN4", JOURNAL OF DAIRY SCIENCE, AMERICAN DAIRY SCIENCE ASSOCIATION. CHAMPAIGN, ILLINOIS, US, vol. 82, no. 7, July 1999 (1999-07-01), pages 1388 - 1393, XP000850204, ISSN: 0022-0302
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