Title:
USE OF CD81 AS THERAPEUTIC TARGET FOR REGULATING INTRACELLULAR LEVELS OF DNTPS
Document Type and Number:
WIPO Patent Application WO/2018/178499
Kind Code:
A3
Abstract:
The invention relates to the field of biomedicine, particularly to the use of agents that can reduce/inhibit the association of the CD81 tetraspanin with the SAMHD1 enyzme in the production of a drug for treating diseases in which the level of dNTPs is relevant, and to screening methods for identifying said agents. The invention further relates to combination therapies for the treatment of HIV.
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Inventors:
YÁÑEZ-MÓ MARÍA (ES)
SUÁREZ MONTERO HENAR (ES)
SÁNCHEZ MADRID FRANCISCO (ES)
ROCHA-PERUGINI VERA (ES)
SUÁREZ MONTERO HENAR (ES)
SÁNCHEZ MADRID FRANCISCO (ES)
ROCHA-PERUGINI VERA (ES)
Application Number:
PCT/ES2018/070291
Publication Date:
November 15, 2018
Filing Date:
April 02, 2018
Export Citation:
Assignee:
UNIV MADRID AUTONOMA (ES)
FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIV LA PRINCESA (ES)
FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIV LA PRINCESA (ES)
International Classes:
A61K31/7088
Other References:
GRIGOROV, BOYAN ET AL.: "A role for CD 81 on the late steps of HIV-1 replication in a chronically infected T cell line", RETROVIROLOGY, vol. 6, no. 1, 2009, pages 1 - 16, XP021051465
KUMAR, AMIT ET AL.: "The macrophage: a therapeutic target in HIV-1 infection", MOLECULAR AND CELLULAR THERAPIES, vol. 2, no. 1, 2 April 2014 (2014-04-02), pages 10 - 24, XP055548626, Retrieved from the Internet
JINWOO AHN: "Functional organization of human SAMHD1 and mechanisms of HIV-1 restriction", BIOL CHEM., vol. 397, no. 4, 1 April 2016 (2016-04-01), pages 373 - 379, XP055548632, Retrieved from the Internet
LAHOUASSA, HICHEM ET AL.: "SAMHD1 restricts HIV-1 by reducing the intracellular pool of deoxynucleotide triphosphates", NATURE IMMUNOLOGY, vol. 13, no. 3, 12 February 2012 (2012-02-12), pages 223 - 228, XP055548638, Retrieved from the Internet
ROCHA- PERU GINI, VERA ET AL.: "CD 81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels", NATURE MICROBIOLOGY, vol. 2, no. 11, 4 September 2017 (2017-09-04), pages 1513 - 1522, XP036429539, Retrieved from the Internet
KUMAR, AMIT ET AL.: "The macrophage: a therapeutic target in HIV-1 infection", MOLECULAR AND CELLULAR THERAPIES, vol. 2, no. 1, 2 April 2014 (2014-04-02), pages 10 - 24, XP055548626, Retrieved from the Internet
JINWOO AHN: "Functional organization of human SAMHD1 and mechanisms of HIV-1 restriction", BIOL CHEM., vol. 397, no. 4, 1 April 2016 (2016-04-01), pages 373 - 379, XP055548632, Retrieved from the Internet
LAHOUASSA, HICHEM ET AL.: "SAMHD1 restricts HIV-1 by reducing the intracellular pool of deoxynucleotide triphosphates", NATURE IMMUNOLOGY, vol. 13, no. 3, 12 February 2012 (2012-02-12), pages 223 - 228, XP055548638, Retrieved from the Internet
ROCHA- PERU GINI, VERA ET AL.: "CD 81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels", NATURE MICROBIOLOGY, vol. 2, no. 11, 4 September 2017 (2017-09-04), pages 1513 - 1522, XP036429539, Retrieved from the Internet
Attorney, Agent or Firm:
FUSTER, Gustavo (ES)
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