Title:
USE OF CHARACTERISTIC POLYPEPTIDE COMPOSITION AND MASS SPECTROMETRY MODEL FOR PREPARING COVID-19 DETECTION PRODUCT
Document Type and Number:
WIPO Patent Application WO/2022/166487
Kind Code:
A1
Abstract:
Provided is a characteristic polypeptide composition for detecting COVID-19. The characteristic polypeptide composition comprises 29 characteristic polypeptides having a specific mass-to-charge ratio. Whether the sample belongs to a patient with COVID-19 can be determined by means of analysing the expression of the characteristic polypeptides. Also provided are uses of a mass spectrometry model prepared according to the characteristic polypeptide composition, a product for diagnosing COVID-19, etc. Searching for multiple combinations of characteristic proteins having differences according to patients with COVID-19/normal people, patients with tuberculosis and COVID-19 type symptoms controls breaks traditional research thought that is only limited to the search for characteristic polypeptides in normal people and patients with COVID-19, effectively avoids infection with false positive results similar to the symptoms of COVID-19, and has a simple operation, low detection costs, high accuracy, and is expected to be used for large-scale screening for COVID-19.
Inventors:
LIAO PU (CN)
SUN WEI (CN)
QIAO LIANG (CN)
LU QIAN (CN)
MA QINGWEI (CN)
SUN WEI (CN)
QIAO LIANG (CN)
LU QIAN (CN)
MA QINGWEI (CN)
Application Number:
PCT/CN2021/142828
Publication Date:
August 11, 2022
Filing Date:
December 30, 2021
Export Citation:
Assignee:
BEIJING YIXINBOCHUANG BIOTECHNOLOGY CO LTD (CN)
International Classes:
G01N27/626; G01N30/02; G01N30/72; G01N30/88; G01N33/68
Foreign References:
| CN111830120A | 2020-10-27 | |||
| CN111378788A | 2020-07-07 | |||
| CN112198214A | 2021-01-08 | |||
| CN111876524A | 2020-11-03 |
Other References:
YAN LING, YI JIA, HUANG CHANGWU, ZHANG JIAN, FU SHUHUI, LI ZHIJIE, LYU QIAN, XU YUAN, WANG KUN, YANG HUAN, MA QINGWEI, CUI XIAOPIN: "Rapid Detection of COVID-19 Using MALDI-TOF-Based Serum Peptidome Profiling", ANALYTICAL CHEMISTRY, vol. 93, no. 11, 23 March 2021 (2021-03-23), US , pages 4782 - 4787, XP055956128, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.0c04590
GOMILA ROSA M., MARTORELL GABRIEL, FRAILE-RIBOT PABLO A., DOMÉNECH-SÁNCHEZ ANTONIO, OLIVER ANTONIO, GARCÍA-GASALLA MERCEDES, ALBER: "Rapid classification and prediction of COVID-19 severity by MALDI-TOF mass spectrometry analysis of serum peptidome", MEDRXIV, 3 November 2020 (2020-11-03), pages 1 - 24, XP055956132, DOI: 10.1101/2020.10.30.20223057
SORELLE JEFFREY A, PATEL KHUSHBU, FILKINS LAURA, PARK JASON Y: "Mass Spectrometry for COVID-19", CLINICAL CHEMISTRY, vol. 66, no. 11, 1 November 2020 (2020-11-01), US , pages 1367 - 1368, XP055956135, ISSN: 0009-9147, DOI: 10.1093/clinchem/hvaa222
RAY K. ILES, ZMUIDINAITE RAMINTA, ILES JASON K., CARNELL GEORGE, SAMPSON ALEX, HEENEY JONATHAN L.: "Development of a Clinical MALDI-ToF Mass Spectrometry Assay for SARS-CoV-2: Rational Design and Multi-Disciplinary Team Work", DIAGNOSTICS, vol. 10, no. 746, 1 January 2020 (2020-01-01), XP055768787, DOI: 10.3390/diagnostics10100746
ROCCA MARÍA FLORENCIA; ZINTGRAFF JONATHAN CRISTIAN; DATTERO MARÍA ELENA; SANTOS LEONARDO SILVA; LEDESMA MARTÍN; VAY CARLOS; PRIETO: "A combined approach of MALDI-TOF mass spectrometry and multivariate analysis as a potential tool for the detection of SARS-CoV-2 virus in nasopharyngeal swabs", JOURNAL OF VIROLOGICAL METHODS, vol. 286, 9 October 2020 (2020-10-09), NL , pages 1 - 7, XP086322541, ISSN: 0166-0934, DOI: 10.1016/j.jviromet.2020.113991
GOMILA ROSA M., MARTORELL GABRIEL, FRAILE-RIBOT PABLO A., DOMÉNECH-SÁNCHEZ ANTONIO, OLIVER ANTONIO, GARCÍA-GASALLA MERCEDES, ALBER: "Rapid classification and prediction of COVID-19 severity by MALDI-TOF mass spectrometry analysis of serum peptidome", MEDRXIV, 3 November 2020 (2020-11-03), pages 1 - 24, XP055956132, DOI: 10.1101/2020.10.30.20223057
SORELLE JEFFREY A, PATEL KHUSHBU, FILKINS LAURA, PARK JASON Y: "Mass Spectrometry for COVID-19", CLINICAL CHEMISTRY, vol. 66, no. 11, 1 November 2020 (2020-11-01), US , pages 1367 - 1368, XP055956135, ISSN: 0009-9147, DOI: 10.1093/clinchem/hvaa222
RAY K. ILES, ZMUIDINAITE RAMINTA, ILES JASON K., CARNELL GEORGE, SAMPSON ALEX, HEENEY JONATHAN L.: "Development of a Clinical MALDI-ToF Mass Spectrometry Assay for SARS-CoV-2: Rational Design and Multi-Disciplinary Team Work", DIAGNOSTICS, vol. 10, no. 746, 1 January 2020 (2020-01-01), XP055768787, DOI: 10.3390/diagnostics10100746
ROCCA MARÍA FLORENCIA; ZINTGRAFF JONATHAN CRISTIAN; DATTERO MARÍA ELENA; SANTOS LEONARDO SILVA; LEDESMA MARTÍN; VAY CARLOS; PRIETO: "A combined approach of MALDI-TOF mass spectrometry and multivariate analysis as a potential tool for the detection of SARS-CoV-2 virus in nasopharyngeal swabs", JOURNAL OF VIROLOGICAL METHODS, vol. 286, 9 October 2020 (2020-10-09), NL , pages 1 - 7, XP086322541, ISSN: 0166-0934, DOI: 10.1016/j.jviromet.2020.113991
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