Title:
USE OF CHELATING AGENTS IN THE TREATMENT OF ATHEROSCLEROTIC CONDITIONS
Document Type and Number:
WIPO Patent Application WO1999033521
Kind Code:
A3
Abstract:
The invention provides the use of dipyridoxyl or aminopolycarboxylic acid based chelating agents, metal chelates and salts thereof, in the manufacture of a therapeutic agent for use in the treatment or prophylaxis of atherosclerosis and related conditions in the human or non-human animal body. Preferred compounds for use in the method of the invention are compounds of formula (I) or a metal chelate or salt thereof (wherein in formula (I) each R<1> independently represents hydrogen or -CH2COR<5>; R<5> represents hydroxy, optionally hydroxylated alkoxy, amino or alkylamido; each R<2> independently represents a group XYR<6>; X represents a bond, or a C1-3 alkylene or oxoalkylene group optionally substituted by a group R<7>; Y represents a bond, an oxygen atom or a group NR<6>; R<6> is a hydrogen atom, a group COOR<8>, an alkyl, alkenyl, cycloalkyl, aryl or aralkyl group optionally substituted by one or more groups selected from COOR<8>, CONR<8>2, NR<8>2, OR<8>, =R<8>, =O, OP(O)(OR<8>)R<7> and OSO3M; R<7> is hydroxy, an optionally hydroxylated, optionally alkoxylated alkyl or aminoalkyl group; R<8> is a hydrogen atom or an optionally hydroxylated, optionally alkoxylated alkyl group; M is a hydrogen atom or one equivalent of a physiologically tolerable cation, e.g. an alkali or alkaline earth cation, an ammonium ion or an organic amine cation, such as a meglumine ion; R<3> represents a C1-8 alkylene group, preferably a C1-6, e.g. a C2-4 alkylene group, a 1,2-cycloalkylene group, or a 1,2-arylene group; each R<4> independently represents hydrogen or C1-3 alkyl; and each R<9> independently may be absent or represents hydrogen, alkyl, hydroxyalkyl or carboxyalkyl).
Inventors:
KARLSSON JAN OLOF GUSTAV (NO)
ANDERSSON ROLF GOERAN GUSTAV (SE)
OLSSON ANDERS (SE)
ZIEDEN BO (SE)
JYNGE PER (NO)
GRIFFITH TUDOR (GB)
GRANT DEREK (NO)
TOWART ROBERTSON (GB)
REFSUM HELGE (NO)
ANDERSSON ROLF GOERAN GUSTAV (SE)
OLSSON ANDERS (SE)
ZIEDEN BO (SE)
JYNGE PER (NO)
GRIFFITH TUDOR (GB)
GRANT DEREK (NO)
TOWART ROBERTSON (GB)
REFSUM HELGE (NO)
Application Number:
PCT/GB1998/003839
Publication Date:
September 02, 1999
Filing Date:
December 18, 1998
Export Citation:
Assignee:
NYCOMED IMAGING AS (NO)
KARLSSON JAN OLOF GUSTAV (NO)
ANDERSSON ROLF GOERAN GUSTAV (SE)
OLSSON ANDERS (SE)
ZIEDEN BO (SE)
JYNGE PER (NO)
GRIFFITH TUDOR (GB)
GRANT DEREK (NO)
TOWART ROBERTSON (GB)
REFSUM HELGE (NO)
KARLSSON JAN OLOF GUSTAV (NO)
ANDERSSON ROLF GOERAN GUSTAV (SE)
OLSSON ANDERS (SE)
ZIEDEN BO (SE)
JYNGE PER (NO)
GRIFFITH TUDOR (GB)
GRANT DEREK (NO)
TOWART ROBERTSON (GB)
REFSUM HELGE (NO)
International Classes:
A61K31/198; A61K31/444; A61K31/44; A61K31/675; A61P9/10; (IPC1-7): A61K31/44
Foreign References:
| EP0391769A1 | 1990-10-10 | |||
| US3838196A | 1974-09-24 | |||
| EP0368223A2 | 1990-05-16 | |||
| EP0292761A2 | 1988-11-30 | |||
| EP0290041A2 | 1988-11-09 | |||
| EP0299795A2 | 1989-01-18 |
Other References:
E. OLSZEWER; J.P. CARTER: "EDTA Chelation Therapy in Chronic Degenerative Disease", MEDICAL HYPOTHESES, vol. 27, no. 1, September 1988 (1988-09-01), pages 41 - 49, XP002097971
"EDTA Chelation Therapy for Arteriosclerotic Heart Disease", MED. LETT. DRUGS THER., vol. 23, no. 1, 1981, pages 51, XP002097972
"EDTA Chelation Therapy for Arteriosclerotic Heart Disease", MED. LETT. DRUGS THER., vol. 23, no. 1, 1981, pages 51, XP002097972
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