Title:
USE OF CHITOSAN FOR STIMULATING BONE HEALING AND BONE FORMATION
Document Type and Number:
WIPO Patent Application WO2006057011
Kind Code:
A3
Abstract:
A use and a composition based on chitosan are provided for stimulating bone healing and bone formation. Chitosan is demonstrated to be a potent osteoinductor and substantially accelerates new bone formation through the endochondrial ossification pathway, by forming cartilage which is subsequently vascularised and mineralized and transformed into a normal healthy bone tissue.
Inventors:
SILBERMANN MICHAEL (IL)
GISLASON JOHANNES (IS)
EINARSSON JON M (IS)
PETER MARTIN (DE)
GISLASON JOHANNES (IS)
EINARSSON JON M (IS)
PETER MARTIN (DE)
Application Number:
PCT/IS2005/000025
Publication Date:
July 13, 2006
Filing Date:
November 29, 2005
Export Citation:
Assignee:
GENIS EHF (IS)
SILBERMANN MICHAEL (IL)
GISLASON JOHANNES (IS)
EINARSSON JON M (IS)
MARTIN PETER (DE)
SILBERMANN MICHAEL (IL)
GISLASON JOHANNES (IS)
EINARSSON JON M (IS)
MARTIN PETER (DE)
International Classes:
A61K31/722; A61L24/08; A61P19/02; A61P19/04; A61P19/08; A61P19/10
Domestic Patent References:
| WO2004028578A1 | 2004-04-08 | |||
| WO2001000792A1 | 2001-01-04 | |||
| WO2004091678A1 | 2004-10-28 | |||
| WO2003051376A1 | 2003-06-26 |
Foreign References:
| US20020082220A1 | 2002-06-27 | |||
| EP1308177A1 | 2003-05-07 | |||
| US20030134810A1 | 2003-07-17 |
Other References:
CHO B C ET AL: "The role of hyaluronic acid, chitosan, and calcium sulfate and their combined effect on early bony consolidation in distraction osteogenesis of a canine model", JOURNAL OF CRANIOFACIAL SURGERY 2002 UNITED STATES, vol. 13, no. 6, 2002, pages 783 - 793, XP008062996, ISSN: 1049-2275
DATABASE WPI Week 19, 29 June 1988 Derwent World Patents Index; Class 883, Page 2, AN 1988-223011, XP002378695, NAMITA KENJI ET AL.: "Remedy for bone disease"
KLOKKEVOLD PERRY R ET AL: "Osteogenesis enhanced by chitosan (poly-N-acetyl glucosaminoglycan) in vitro", JOURNAL OF PERIODONTOLOGY, vol. 67, no. 11, 1996, pages 1170 - 1175, XP008062982, ISSN: 0022-3492
YAMADA SHIZUKA ET AL: "Mineralization of matrix vesicles isolated from a human osteosarcoma cell line in culture with water-soluble chitosan-containing medium.", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, vol. 66A, no. 3, 1 September 2003 (2003-09-01), pages 500 - 506, XP002378691, ISSN: 0021-9304
DATABASE WPI Week 20, 16 December 2002 Derwent World Patents Index; Class 032, Page 9, AN 2003-297156, XP002378696, HYUN B.H. ET AL.: "Low molecular weight phosphorylated chitosan oligosaccharide as calcium absorption accelerating agent"
DATABASE WPI Week 20, 11 October 2002 Derwent World Patents Index; Class 046, Page 6, AN 2003-154643, XP002378697, CHO BYEONG CHAE ET AL.: "Composite for facilitating osteogenesis and osteosclerosis"
CHO B C ET AL: "Effect of calcium sulfate-chitosan composite: Pellet on bone formation in bone defect", JOURNAL OF CRANIOFACIAL SURGERY 2005 UNITED STATES, vol. 16, no. 2, 2005, pages 213 - 224, XP008062997, ISSN: 1049-2275
IWATA H ET AL: "Effects of chitosan oligosaccharides on the femur trabecular structure in ovariectomized rats", ORAL RADIOLOGY 2005 JAPAN, vol. 21, no. 1, 2005, pages 19 - 22, XP008062990, ISSN: 0911-6028
DATABASE WPI Week 19, 29 June 1988 Derwent World Patents Index; Class 883, Page 2, AN 1988-223011, XP002378695, NAMITA KENJI ET AL.: "Remedy for bone disease"
KLOKKEVOLD PERRY R ET AL: "Osteogenesis enhanced by chitosan (poly-N-acetyl glucosaminoglycan) in vitro", JOURNAL OF PERIODONTOLOGY, vol. 67, no. 11, 1996, pages 1170 - 1175, XP008062982, ISSN: 0022-3492
YAMADA SHIZUKA ET AL: "Mineralization of matrix vesicles isolated from a human osteosarcoma cell line in culture with water-soluble chitosan-containing medium.", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, vol. 66A, no. 3, 1 September 2003 (2003-09-01), pages 500 - 506, XP002378691, ISSN: 0021-9304
DATABASE WPI Week 20, 16 December 2002 Derwent World Patents Index; Class 032, Page 9, AN 2003-297156, XP002378696, HYUN B.H. ET AL.: "Low molecular weight phosphorylated chitosan oligosaccharide as calcium absorption accelerating agent"
DATABASE WPI Week 20, 11 October 2002 Derwent World Patents Index; Class 046, Page 6, AN 2003-154643, XP002378697, CHO BYEONG CHAE ET AL.: "Composite for facilitating osteogenesis and osteosclerosis"
CHO B C ET AL: "Effect of calcium sulfate-chitosan composite: Pellet on bone formation in bone defect", JOURNAL OF CRANIOFACIAL SURGERY 2005 UNITED STATES, vol. 16, no. 2, 2005, pages 213 - 224, XP008062997, ISSN: 1049-2275
IWATA H ET AL: "Effects of chitosan oligosaccharides on the femur trabecular structure in ovariectomized rats", ORAL RADIOLOGY 2005 JAPAN, vol. 21, no. 1, 2005, pages 19 - 22, XP008062990, ISSN: 0911-6028
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