Title:
USE OF COLORED METAL BINDING PROTEINS
Document Type and Number:
WIPO Patent Application WO2001011358
Kind Code:
A3
Abstract:
The present invention is directed to reporter molecules and tags that may be used to monitor a target substance in a biological system. More particularly, the present invention relates to the use of an apo metal binding protein as a reporter molecule or tag. An apo metal binding protein may be bound to a protein or tissue or introduced into a cell. The invention also relates to methods of utilizing the apo metal binding protein for detecting a cell expressing a protein of interest, localizing a protein in a cell, and designing a therapeutic agent for treating a disease or infection.
Inventors:
DIERYNCK INGE (BE)
ROELANT CHRISTIAAN HUBERT SIMO (BE)
PAUWELS RUDI WILFRIED JAN (BE)
VAN ACKER KOENRAAD LODEWIJK AU (BE)
DE KERPEL JAN OCTAAF ANTOON (BE)
ROELANT CHRISTIAAN HUBERT SIMO (BE)
PAUWELS RUDI WILFRIED JAN (BE)
VAN ACKER KOENRAAD LODEWIJK AU (BE)
DE KERPEL JAN OCTAAF ANTOON (BE)
Application Number:
PCT/EP2000/007895
Publication Date:
November 14, 2002
Filing Date:
August 04, 2000
Export Citation:
Assignee:
TIBOTEC NV (BE)
DIERYNCK INGE (BE)
ROELANT CHRISTIAAN HUBERT SIMO (BE)
PAUWELS RUDI WILFRIED JAN (BE)
VAN ACKER KOENRAAD LODEWIJK AU (BE)
DE KERPEL JAN OCTAAF ANTOON (BE)
DIERYNCK INGE (BE)
ROELANT CHRISTIAAN HUBERT SIMO (BE)
PAUWELS RUDI WILFRIED JAN (BE)
VAN ACKER KOENRAAD LODEWIJK AU (BE)
DE KERPEL JAN OCTAAF ANTOON (BE)
International Classes:
G01N33/50; G01N33/58; (IPC1-7): G01N33/58; G01N33/50
Domestic Patent References:
| WO1997009431A1 | 1997-03-13 |
Foreign References:
| US5210019A | 1993-05-11 |
Other References:
HOITINK, C.W.G. ET AL.: "Isolation and sequencing of the Alcaligenes denitrificans azurin-encoding gene: comparison with the genes encoding blue copper proteins from Pseudomonas aeruginosa and Alcaligenes faecalis.", GENE, vol. 90, 1990, pages 15-20, XP002150598
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