Title:
USE OF COMPOSITION COMPRISING ASTILBIN AND/OR ISOMER THEREOF IN PREPARATION OF DRUG FOR TREATING PSORIASIS
Document Type and Number:
WIPO Patent Application WO/2023/065376
Kind Code:
A1
Abstract:
A pharmaceutical composition comprising astilbin and/or an isomer thereof for treating psoriasis, as well as a preparation and an application thereof. The pharmaceutical composition further comprises a polyphenol selected from the following: one or more of engeletin or an isomer thereof, taxifolin, naringenin, quercetin, and resveratrol. The pharmaceutical composition has significant therapeutic effects for an imiquimod-induced psoriasis-like mouse model and a mouse tail scale model. The combination of astilbin and/or an isomer thereof and a polyphenol in the pharmaceutical composition has a significant synergistic effect, and the effect thereof is better than that of using astilbin alone. Furthermore, the pharmaceutical composition is safe and has no adverse reactions, has broad application prospects in the preparation of drugs for treating psoriasis, and has important social and economic benefits.
Inventors:
TANG YINGZHAN (CN)
JIANG TAO (CN)
ZENG LIJIE (CN)
ZENG CHEN (CN)
ZHANG LUYONG (CN)
LIU JUYAN (CN)
MA SAIYAN (CN)
CHEN QIMING (CN)
SU RUIHUI (CN)
CHEN LISI (CN)
WANG CHUANYI (CN)
PENG HONGYING (CN)
JIANG TAO (CN)
ZENG LIJIE (CN)
ZENG CHEN (CN)
ZHANG LUYONG (CN)
LIU JUYAN (CN)
MA SAIYAN (CN)
CHEN QIMING (CN)
SU RUIHUI (CN)
CHEN LISI (CN)
WANG CHUANYI (CN)
PENG HONGYING (CN)
Application Number:
PCT/CN2021/126302
Publication Date:
April 27, 2023
Filing Date:
October 26, 2021
Export Citation:
Assignee:
GUANGZHOU BAIYUNSHAN JINGXIUTANG PHARMACEUTICAL COMPANY LTD (CN)
International Classes:
A61K31/7048; A61K31/05; A61P17/06; A61P29/00
Foreign References:
| CN106389453A | 2017-02-15 | |||
| CN105891404A | 2016-08-24 | |||
| CN111450107A | 2020-07-28 | |||
| US20030152588A1 | 2003-08-14 | |||
| CN103463531A | 2013-12-25 |
Other References:
LIU, LIJUAN ET AL.: "Discussion on the Synergy Rule of PSORI-CM02 in Treating Psoriasis Based on Pharmacodynamic-component Analysis", CHINESE JOURNAL OF TRADITIONAL CHINESE MEDICINE (JOURNAL OF CHINESE MEDICINE), vol. 35, no. 8, 31 August 2020 (2020-08-31), XP009545156
Attorney, Agent or Firm:
BEIJING CEMO LEADER INTELLECTUAL PROPERTY AGENCY (CN)
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