Title:
USE OF A COMPOUND HAVING TWO GOLD (I) ATOMS EACH COVALENTLY BONDED TO A CARBON ATOM IN A COVALENT LINK CONNECTING THE TWO GOLD (I) ATOMS FOR THE TREATMENT OF CANCER
Document Type and Number:
WIPO Patent Application WO2005058421
Kind Code:
A3
Abstract:
The invention relates to the treatment of cancers, in particular, cancers that are resistant to platinum based chemotherapeutic agents. A pharmaceutical composition for the treatment of cancer comprising an effective amount of a compound having two gold(I) atoms each covalently bonded to a carbon atom in a covalent link connecting the two gold(I) atoms and a pharmaceutically acceptable excipient.
Inventors:
FLOWER KEVIN (GB)
MCGOWN ALAN (GB)
MCGOWN ALAN (GB)
Application Number:
PCT/GB2004/005440
Publication Date:
August 18, 2005
Filing Date:
December 20, 2004
Export Citation:
Assignee:
UNIV SALFORD (GB)
UMIST VENTURES LTD (GB)
PATERSON INST FOR CANCER RES (GB)
FLOWER KEVIN (GB)
MCGOWN ALAN (GB)
UMIST VENTURES LTD (GB)
PATERSON INST FOR CANCER RES (GB)
FLOWER KEVIN (GB)
MCGOWN ALAN (GB)
International Classes:
A61K31/66; (IPC1-7): A61P35/00; A61K31/66
Foreign References:
| EP0189306A2 | 1986-07-30 |
Other References:
BARNARD, PETER J. ET AL: "Mitochondrial permeability transition induced by dinuclear gold(I)-carbene complexes: potential new antimitochondrial antitumour agents", JOURNAL OF INORGANIC BIOCHEMISTRY , 98(10), 1642-1647 CODEN: JIBIDJ; ISSN: 0162-0134, 2004, XP002329454
SCHMIDBAUR H ET AL: "SOME GOLD I COMPLEXES OF PHOSPHORUS YLIDES AND THEIR EFFECT IN GOLD THERAPY WITH THE ADJUVANT ARTHRITIS MODEL", ZEITSCHRIFT FUER NATURFORSCHUNG TEIL B ANORGANISCHE CHEMIE ORGANISCHE CHEMIE, vol. 33, no. 11, 1978, pages 1325 - 1329, XP009048242, ISSN: 0340-5087
ROZENBERG, V. I. ET AL: "Mono(tin)- and bis(gold)-metalated covalently bonded .sigma.-aryl derivatives in the [2.2]paracyclophane series", METALLOORGANICHESKAYA KHIMIYA , 4(3), 686-8 CODEN: MEKHEX; ISSN: 0235-0114, 1991, XP009048161
CAGNOLI, MONICA ET AL: "Synthesis and biological activity of gold and tin compounds in ovarian cancer cells", ANTI-CANCER DRUGS , 9(7), 603-610 CODEN: ANTDEV; ISSN: 0959-4973, 1998, XP000915664
SCHMIDBAUR H ET AL: "SOME GOLD I COMPLEXES OF PHOSPHORUS YLIDES AND THEIR EFFECT IN GOLD THERAPY WITH THE ADJUVANT ARTHRITIS MODEL", ZEITSCHRIFT FUER NATURFORSCHUNG TEIL B ANORGANISCHE CHEMIE ORGANISCHE CHEMIE, vol. 33, no. 11, 1978, pages 1325 - 1329, XP009048242, ISSN: 0340-5087
ROZENBERG, V. I. ET AL: "Mono(tin)- and bis(gold)-metalated covalently bonded .sigma.-aryl derivatives in the [2.2]paracyclophane series", METALLOORGANICHESKAYA KHIMIYA , 4(3), 686-8 CODEN: MEKHEX; ISSN: 0235-0114, 1991, XP009048161
CAGNOLI, MONICA ET AL: "Synthesis and biological activity of gold and tin compounds in ovarian cancer cells", ANTI-CANCER DRUGS , 9(7), 603-610 CODEN: ANTDEV; ISSN: 0959-4973, 1998, XP000915664
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