Title:
USE OF CORTISOL-SEQUESTERING AGENTS FOR THE TREATMENT OF HYPERCORTISOLAEMIA RELATED DISORDERS
Document Type and Number:
WIPO Patent Application WO2002036105
Kind Code:
A3
Abstract:
The invention relates to the use of cortisol-sequestering agents for the preparation of a medicament for the treatment of hypercortisolaemia related disorders, especially for the treatment of major depression; to pharmaceutical compositions comprising a cortisol-sequestering agent, and to the cortisol-sequestering agent 6-per-deoxy-6-per-(2,3-dihydroxypropylthio)- gamma -cyclodextrin.
Inventors:
ZHANG MINGQUIANG (GB)
HILL DAVID ROBERT (GB)
REES DAVID (SE)
HILL DAVID ROBERT (GB)
REES DAVID (SE)
Application Number:
PCT/EP2001/012267
Publication Date:
October 31, 2002
Filing Date:
October 30, 2001
Export Citation:
Assignee:
AKZO NOBEL NV (US)
ZHANG MINGQUIANG (GB)
HILL DAVID ROBERT (GB)
REES DAVID (SE)
ZHANG MINGQUIANG (GB)
HILL DAVID ROBERT (GB)
REES DAVID (SE)
International Classes:
A61K31/00; A61K31/724; A61P5/06; A61P25/18; A61P25/22; A61K45/00; A61P25/24; C08B37/16; (IPC1-7): A61K31/724; A61K31/00; A61P25/18; A61P25/22; A61P25/24
Domestic Patent References:
| WO1998054221A1 | 1998-12-03 | |||
| WO2001040316A1 | 2001-06-07 |
Foreign References:
| EP0447171A2 | 1991-09-18 | |||
| GB2109381A | 1983-06-02 | |||
| US6090794A | 2000-07-18 | |||
| US4814333A | 1989-03-21 |
Other References:
MARK H. BEERS AND ROBERT BERKOW: "The Merck Manual of Diagnosis and Therapy, Seventeenth Edition", 1999, MERCK RESEARCH LABORATORIES, WHITEHOUSE STATION, N.J., XP002204208
CHANG-CHUN LING AND RAPHAEL DARCY: "6-S-Hydroxyethylated 6-Thiocyclodextrins: Expandable Host Molecules", J. CHEM. SOC. CHEM. COMMUN., vol. 2, 1993, pages 203 - 205, XP001074003
DATABASE WPI Week 198930, Derwent World Patents Index; AN 1989-216583, XP002164380, ISHIDA HIROSHI: "Immunoassay method of hardly water soluble antigen"
KOJRO E ET AL: "CHOLESTEROL DEPLETION ENHANCES CLEAVAGE OF APP BY THE ALPHA-SECRETASE ADAM 10", SOCIETY FOR NEUROSCIENCE ABSTRACTS, SOCIETY FOR NEUROSCIENCE, US, vol. 26, no. 1/2, 2000, pages COMPLETE, XP000990932, ISSN: 0190-5295
MURPHY B E P: "STEROIDS AND DEPRESSION", JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 38, no. 5, 1991, pages 537 - 560, XP000990952, ISSN: 0960-0760
CHANG-CHUN LING AND RAPHAEL DARCY: "6-S-Hydroxyethylated 6-Thiocyclodextrins: Expandable Host Molecules", J. CHEM. SOC. CHEM. COMMUN., vol. 2, 1993, pages 203 - 205, XP001074003
DATABASE WPI Week 198930, Derwent World Patents Index; AN 1989-216583, XP002164380, ISHIDA HIROSHI: "Immunoassay method of hardly water soluble antigen"
KOJRO E ET AL: "CHOLESTEROL DEPLETION ENHANCES CLEAVAGE OF APP BY THE ALPHA-SECRETASE ADAM 10", SOCIETY FOR NEUROSCIENCE ABSTRACTS, SOCIETY FOR NEUROSCIENCE, US, vol. 26, no. 1/2, 2000, pages COMPLETE, XP000990932, ISSN: 0190-5295
MURPHY B E P: "STEROIDS AND DEPRESSION", JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 38, no. 5, 1991, pages 537 - 560, XP000990952, ISSN: 0960-0760
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