Title:
USE OF A CYCLOOXYGENASE-2 INHIBITOR AND ONE OR MORE ANTINEOPLASTIC AGENTS FOR COMBINATION THERAPY IN NEOPLASIA
Document Type and Number:
WIPO Patent Application WO2000038730
Kind Code:
A3
Abstract:
The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of a cyclooxygenase-2 inhibitor and an antineoplastic agent.
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Inventors:
MCKEARN JOHN P (US)
GORDON GARY (US)
CUNNINGHAM JAMES J (US)
GATELY STEPHEN T (US)
KOKI ALANE T (US)
MASFERRER JAIME L (US)
GORDON GARY (US)
CUNNINGHAM JAMES J (US)
GATELY STEPHEN T (US)
KOKI ALANE T (US)
MASFERRER JAIME L (US)
Application Number:
PCT/US1999/030693
Publication Date:
November 02, 2000
Filing Date:
December 22, 1999
Export Citation:
Assignee:
SEARLE & CO (US)
MCKEARN JOHN P (US)
GORDON GARY (US)
CUNNINGHAM JAMES J (US)
GATELY STEPHEN T (US)
KOKI ALANE T (US)
MASFERRER JAIME L (US)
MCKEARN JOHN P (US)
GORDON GARY (US)
CUNNINGHAM JAMES J (US)
GATELY STEPHEN T (US)
KOKI ALANE T (US)
MASFERRER JAIME L (US)
International Classes:
A61K31/00; A61K31/07; A61K31/122; A61K33/243; A61K31/135; A61K45/00; A61K31/136; A61K31/138; A61K31/16; A61K31/165; A61K31/166; A61K31/18; A61K31/191; A61K31/192; A61K31/197; A61K31/198; A61K31/203; A61K31/255; A61K31/28; A61K31/282; A61K31/337; A61K31/341; A61K31/351; A61K31/353; A61K31/36; A61K31/381; A61K31/402; A61K31/415; A61K31/4162; A61K31/4164; A61K31/4168; A61K31/4178; A61K31/4184; A61K31/4188; A61K31/4196; A61K31/42; A61K31/421; A61K31/422; A61K31/425; A61K31/427; A61K31/429; A61K31/435; A61K31/4353; A61K31/437; A61K31/4375; A61K31/44; A61K31/4402; A61K31/4418; A61K31/4427; A61K31/4433; A61K31/4439; A61K31/444; A61K31/445; A61K31/4453; A61K31/45; A61K31/451; A61K31/4535; A61K31/4545; A61K31/4709; A61K31/4741; A61K31/4745; A61K31/475; A61K31/496; A61K31/501; A61K31/505; A61K31/506; A61K31/51; A61K31/519; A61K31/525; A61K31/541; A61K31/55; A61K31/5513; A61K31/566; A61K31/567; A61K31/569; A61K31/57; A61K31/575; A61K31/66; A61K31/664; A61K31/675; A61K31/704; A61K31/7048; A61K31/7068; A61K33/04; A61K33/10; A61K38/00; A61K39/395; A61K41/00; A61K45/06; A61P1/00; A61P11/00; A61P13/10; A61P15/00; A61P15/14; A61P17/00; A61P35/00; A61P41/00; A61P43/00; C07D211/54; C07D211/66; C07D211/96; C07D213/74; C07D261/18; C07D309/08; C07D401/06; C07D401/12; C07D403/12; C07D405/12; C07D413/12; C07D417/12; C07D471/04; C07K5/023; C07K5/062; C07K16/18; (IPC1-7): A61K45/06; A61K41/00; A61P35/00
Domestic Patent References:
| WO1998016227A1 | 1998-04-23 |
Foreign References:
| EP0927555A1 | 1999-07-07 |
Other References:
BIOLOGICAL ABSTRACTS, vol. 00, Philadelphia, PA, US; abstract no. prev199800349798, BARNI, SANDRO (1) ET AL: "Clinical efficacy of the aromatase inhibitor anastrozole in relation to prolactin secretion in heavily pretreated metastatic breast cancer." XP002133936
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