Title:
USE OF CYCLOPENTENONE DERIVATIVES FOR BONE AND PERIODONTAL REGENERATION
Document Type and Number:
WIPO Patent Application WO2001051054
Kind Code:
A3
Abstract:
Methods for bone and periodontal tissue regeneration using cyclopentenone prostanoids and their agonists, and methods to retard pathophysiological calcification using cyclopentenone antagonists.
More Like This:
Inventors:
OFFENBACHER STEVEN (US)
COOPER LYNDON F (US)
FRITZ MICHAEL E (US)
COOPER LYNDON F (US)
FRITZ MICHAEL E (US)
Application Number:
PCT/US2001/001105
Publication Date:
October 30, 2003
Filing Date:
January 12, 2001
Export Citation:
Assignee:
UNIV NORTH CAROLINA CHAPEL HILL (US)
UNIV EMORY (US)
OFFENBACHER STEVEN (US)
COOPER LYNDON F (US)
FRITZ MICHAEL E (US)
UNIV EMORY (US)
OFFENBACHER STEVEN (US)
COOPER LYNDON F (US)
FRITZ MICHAEL E (US)
International Classes:
A61K31/00; A61K31/122; A61K31/557; A61K31/5575; A61P19/10; G01N33/88; A61K9/16; (IPC1-7): A61K31/5575; A61P19/10
Domestic Patent References:
| WO2000031084A1 | 2000-06-02 | |||
| WO1994028889A1 | 1994-12-22 |
Foreign References:
| EP0911321A2 | 1999-04-28 | |||
| US5700835A | 1997-12-23 |
Other References:
PATENT ABSTRACTS OF JAPAN vol. 014, no. 171 (C - 0706) 3 April 1990 (1990-04-03)
TAKAGI T ET AL: "Effect of prostaglandin D2 on the femoral bone mineral density in ovariectomized rats.", CALCIFIED TISSUE INTERNATIONAL, (1993 JUN) 52 (6) 442-6., XP001007074
KOSHIHARA Y ET AL: "Prostaglandin D2 stimulates calcification of human osteoblastic cells.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (1989 MAR 31) 159 (3) 1206-12., XP001007069
TASAKI Y ET AL: "Prostaglandin D2 metabolite stimulates collagen synthesis by human osteoblasts during calcification.", PROSTAGLANDINS, (1991 APR) 41 (4) 303-13., XP001007083
KOSHIHARA Y ET AL: "Prostaglandin D2 stimulates calcification by human osteoblastic cells.", ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH, (1991) 21B 847-50., XP001007085
KOSHIHARA, Y.: "Antitumor prostaglandins facilitate mineralization by human osteoblasts", DEV. ONCOL. (1993), 71(EICOSANOIDS OTHER BIOACT. LIPIDS CANCER, INFLAMMATION RADIAT. INJ.), 559-62, XP001007172
RICHE, E. L. ET AL: "Development of. DELTA. 12 prostaglandin J2 as a new drug for bone regeneration", PROC. INT. SYMP. CONTROLLED RELEASE BIOACT. MATER. (2000), 27TH, 1190-1191, XP001000277
TAKAGI T ET AL: "Effect of prostaglandin D2 on the femoral bone mineral density in ovariectomized rats.", CALCIFIED TISSUE INTERNATIONAL, (1993 JUN) 52 (6) 442-6., XP001007074
KOSHIHARA Y ET AL: "Prostaglandin D2 stimulates calcification of human osteoblastic cells.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (1989 MAR 31) 159 (3) 1206-12., XP001007069
TASAKI Y ET AL: "Prostaglandin D2 metabolite stimulates collagen synthesis by human osteoblasts during calcification.", PROSTAGLANDINS, (1991 APR) 41 (4) 303-13., XP001007083
KOSHIHARA Y ET AL: "Prostaglandin D2 stimulates calcification by human osteoblastic cells.", ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH, (1991) 21B 847-50., XP001007085
KOSHIHARA, Y.: "Antitumor prostaglandins facilitate mineralization by human osteoblasts", DEV. ONCOL. (1993), 71(EICOSANOIDS OTHER BIOACT. LIPIDS CANCER, INFLAMMATION RADIAT. INJ.), 559-62, XP001007172
RICHE, E. L. ET AL: "Development of. DELTA. 12 prostaglandin J2 as a new drug for bone regeneration", PROC. INT. SYMP. CONTROLLED RELEASE BIOACT. MATER. (2000), 27TH, 1190-1191, XP001000277
Download PDF: