Title:
USE OF CYP450 INHIBITOR IN INHIBITING OR KILLING MITES AND TREATING DRY EYE SYNDROME
Document Type and Number:
WIPO Patent Application WO/2022/257986
Kind Code:
A1
Abstract:
The present invention relates to the use of a CYP450 inhibitor in inhibiting or killing mites and treating dry eye syndrome. A large number of experiments show that the CYP450 inhibitor can be used for inhibiting and killing mites, can effectively shorten the survival time of mites, and can be used for a mite killing and inhibiting product (such as drugs, cosmetics, daily necessities, etc.). In addition, it is found that the CYP450 inhibitor may also be used in the treatment of dry eye syndrome, and can effectively alleviate and improve the symptoms of dry eye syndrome.
Inventors:
WEI LAI (CN)
OUYANG HUI (CN)
OUYANG HUI (CN)
Application Number:
PCT/CN2022/097684
Publication Date:
December 15, 2022
Filing Date:
June 08, 2022
Export Citation:
Assignee:
SMILEBIOTEK GUANGZHOU LTD (CN)
International Classes:
A61K45/06; A61K31/135; A61K31/4164; A61P27/02; A61P33/02; A61P33/14
Domestic Patent References:
| WO2019175713A1 | 2019-09-19 |
Foreign References:
| CN102552114A | 2012-07-11 | |||
| CN110035763A | 2019-07-19 | |||
| CN102727425A | 2012-10-17 |
Other References:
LIANG YUE, MU HAI-LONG;HE TAO-TAO;ZHANG KAI-RUI;LI YUAN-YUAN;FAN YUN-PENG;MA WU-REN;LIU YING-QIU;SONG XIAO-PING: "Treatment Effect of Eugenia caryophyllata Extract Microemulsion against Psoroptes cuniculi Infection", PROGRESS IN VETERINARY MEDICINE, vol. 42, no. 2, 7 February 2021 (2021-02-07), pages 132 - 137, XP093012315, ISSN: 1007-5038, DOI: 10.16437/j.cnki.1007-5038.2021.02.025
SHANG XIAOFEI: "Bioactivities and Modes of Action of Four Kinds of Natural Products", CHINESE DOCTORAL AND MASTER'S DISSERTATIONS FULL-TEXT DATABASE, AGRICULTURAL SCIENCE AND TECHNOLOGY, no. 2, 15 February 2020 (2020-02-15), XP093012318
CHEN LIHAO, HONG-ZHE LI;JUN PENG;HUI-YING WANG;XIAO-LEI YAO;QING-HUA PENG: "Ocular surface diseases related to Demodex and their diagnosis and treatment", GUOJI YANKE ZAZHI = INTERNATIONAL JOURNAL OF OPHTHALMOLOGY / INTERNATIONAL EYE SCIENCE, ZHONGHUA YIXUEHUI, XIAN FENHUI,, CN, vol. 20, no. 9, 30 September 2020 (2020-09-30), CN , pages 1547 - 1550, XP093012319, ISSN: 1672-5123, DOI: 10.3980/j.issn.1672-5123.2020.9.16
"Ocular Demodicosis as a Potential Cause of Ocular Surface Inflammation", CORNEA, vol. 36
KARINCAOGLU, Y.TEPE, B.KALAYCI, B.ATAMBAY, M.SEYHAN, M.: "Is Demodex folliculorum an aetiological factor in seborrhoeic dermatitis?", CLINICAL AND EXPERIMENTAL DERMATOLOGY, vol. 34, pages e516 - 520, XP071607261, DOI: 10.1111/j.1365-2230.2009.03343.x
CHEN, W.PLEWIG, G.: "Human demodicosis: revisit and a proposed classification", THE BRITISH JOURNAL OF DERMATOLOGY, vol. 170, pages 1219 - 1225, XP071167748, DOI: 10.1111/bjd.12850
SHANG XIAOFEI: "Bioactivities and Modes of Action of Four Kinds of Natural Products", CHINESE DOCTORAL AND MASTER'S DISSERTATIONS FULL-TEXT DATABASE, AGRICULTURAL SCIENCE AND TECHNOLOGY, no. 2, 15 February 2020 (2020-02-15), XP093012318
CHEN LIHAO, HONG-ZHE LI;JUN PENG;HUI-YING WANG;XIAO-LEI YAO;QING-HUA PENG: "Ocular surface diseases related to Demodex and their diagnosis and treatment", GUOJI YANKE ZAZHI = INTERNATIONAL JOURNAL OF OPHTHALMOLOGY / INTERNATIONAL EYE SCIENCE, ZHONGHUA YIXUEHUI, XIAN FENHUI,, CN, vol. 20, no. 9, 30 September 2020 (2020-09-30), CN , pages 1547 - 1550, XP093012319, ISSN: 1672-5123, DOI: 10.3980/j.issn.1672-5123.2020.9.16
"Ocular Demodicosis as a Potential Cause of Ocular Surface Inflammation", CORNEA, vol. 36
KARINCAOGLU, Y.TEPE, B.KALAYCI, B.ATAMBAY, M.SEYHAN, M.: "Is Demodex folliculorum an aetiological factor in seborrhoeic dermatitis?", CLINICAL AND EXPERIMENTAL DERMATOLOGY, vol. 34, pages e516 - 520, XP071607261, DOI: 10.1111/j.1365-2230.2009.03343.x
CHEN, W.PLEWIG, G.: "Human demodicosis: revisit and a proposed classification", THE BRITISH JOURNAL OF DERMATOLOGY, vol. 170, pages 1219 - 1225, XP071167748, DOI: 10.1111/bjd.12850
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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