Title:
USE OF DEUBIQUITINATING ENZYME IN PREPARATION OF DRUG FOR PREVENTING OR TREATING ACUTE GRAFT-VERSUS-HOST DISEASE AND GRAFT-VERSUS-LEUKEMIA
Document Type and Number:
WIPO Patent Application WO/2023/134121
Kind Code:
A1
Abstract:
Provided is a use of a deubiquitinating enzyme BRCC3 in the preparation of a drug for preventing or treating acute graft-versus-host disease (aGVHD) and graft-versus-leukemia (GVL). A use of a deubiquitinating enzyme BRCC3 in the preparation of a drug for preventing and treating graft-versus-host disease is researched and explored by means of animal experiments. The results show that BRCC3 has the effect of inhibiting aGVHD after allogeneic hematopoietic stem cell transplantation, can inhibit donor T cell activation and the functions of T cells and inhibit proliferation of macrophages, down-regulates the ubiquitylation of TRIM25 by a proteasome pathway, stabilizes the protein level of TRIM25, then promotes secretion of IFNβ, inhibits occurrence and development of aGVHD, retains a GVL effect, and thus has great application prospects.
Inventors:
XU YANG (CN)
CHENG QIAO (CN)
WU DEPEI (CN)
LIU YIN (CN)
ZHENG HUI (CN)
ZHU TINGTING (CN)
CHENG QIAO (CN)
WU DEPEI (CN)
LIU YIN (CN)
ZHENG HUI (CN)
ZHU TINGTING (CN)
Application Number:
PCT/CN2022/100866
Publication Date:
July 20, 2023
Filing Date:
June 23, 2022
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
A61K38/48; A61P35/02; A61P37/06
Foreign References:
| CN114191544A | 2022-03-18 | |||
| CN110257357A | 2019-09-20 | |||
| US20140271668A1 | 2014-09-18 |
Other References:
CHENG QIAO, FENG QIAN, XU YANG, ZUO YIBO, LIU JIN, YUAN YUKANG, MIAO YING, LIU YIN, LEI LEI, GUO TINGTING, ZHANG LITING, WU DEPEI,: "BRCC36 functions noncatalytically to promote antiviral response by maintaining STAT1 protein stability", EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-VCH, HOBOKEN, USA, vol. 51, no. 2, 1 February 2021 (2021-02-01), Hoboken, USA, pages 296 - 310, XP093079038, ISSN: 0014-2980, DOI: 10.1002/eji.202048537
Attorney, Agent or Firm:
CENTRAL SOUTH WELL INTELLECTUAL PROPERTY OFFICE (CN)
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