Title:
USE FOR DUAL TARGET VASCULAR INHIBITOR IN PREPARING DRUGS FOR PREVENTING OR TREATING FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2021/004549
Kind Code:
A1
Abstract:
The present invention relates to the field of using a dual target vascular inhibitor to treat fibrosis diseases. More specifically, provided is a use for a dual target vascular inhibitor in preparing drugs for preventing or treating fibrosis diseases.
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Inventors:
JIANG JING (CN)
KOU XIANGYING (CN)
SUN YEYING (CN)
LI SHENJUN (CN)
KOU XIANGYING (CN)
SUN YEYING (CN)
LI SHENJUN (CN)
Application Number:
PCT/CN2020/105955
Publication Date:
January 14, 2021
Filing Date:
July 30, 2020
Export Citation:
Assignee:
BINZHOU MEDICAL UNIV (CN)
REMEGEN CO LTD (CN)
REMEGEN CO LTD (CN)
International Classes:
A61K38/17; A61K47/68; A61P1/16; A61P11/00; A61P13/12
Domestic Patent References:
| WO2018160739A1 | 2018-09-07 |
Foreign References:
| CN105983093A | 2016-10-05 | |||
| CN102219859A | 2011-10-19 | |||
| CN106084062A | 2016-11-09 | |||
| US20050009894A1 | 2005-01-13 |
Other References:
XIANGYING KOU, SUN YEYING, LI SHENJUN, BIAN WEIHUA, LIU ZHIHAO, ZHANG DAOLAI, JIANG JING: "Pharmacology Study of the Multiple Angiogenesis Inhibitor RC28-E on Anti-Fibrosis in a Chemically Induced Lung Injury Model", BIOMOLECULES, vol. 9, no. 11, 24 October 2019 (2019-10-24), pages 1 - 19, XP055771886, DOI: 10.3390/biom9110644
LADDHA ANKIT P; KULKARNI YOGESH A: "VEGF and FGF-2：Promising Targets for the Treatment of Respiratory Disorders", RESPIRATORY MEDICINE, vol. 156, 8 August 2019 (2019-08-08), pages 33 - 46, XP085793775, ISSN: 0954-6111, DOI: 10.1016/j.rmed.2019.08.003
HUANG GUIPING , LIU DAI-SHUN , WU KAI-FENG , ZHANG WEI , GONG LING , ZHU HONG-IAN , TANG HONG-BO , ZHONG CHENG-YAO: "Nintedanib Ameliorates Lipopolysaccharide-induced Lung Fibrosis in Acute Respiratory Distress Syndrome", CHINESE JOURNAL OF NEW DRUGS, vol. 25, no. 14, 27 July 2016 (2016-07-27), pages 1652 - 1659, XP055771895, ISSN: 1003-3734
CHAUDHARY N I; ROTH G J; HILBERG F; MUELLER-QUERNHEIM J; PRASSE A; ZISSEL G; SCHNAPP A; PARK J E: "Inhibition of PDGF, VEGF and FGF Signalling Attenuates Fibrosis", EUROPEAN RESPIRATORY JOURNAL, vol. 29, no. 5, 1 May 2007 (2007-05-01), pages 976 - 985, XP009109569, ISSN: 0903-1936, DOI: 10.1183/09031936.00152106
LADDHA ANKIT P; KULKARNI YOGESH A: "VEGF and FGF-2：Promising Targets for the Treatment of Respiratory Disorders", RESPIRATORY MEDICINE, vol. 156, 8 August 2019 (2019-08-08), pages 33 - 46, XP085793775, ISSN: 0954-6111, DOI: 10.1016/j.rmed.2019.08.003
HUANG GUIPING , LIU DAI-SHUN , WU KAI-FENG , ZHANG WEI , GONG LING , ZHU HONG-IAN , TANG HONG-BO , ZHONG CHENG-YAO: "Nintedanib Ameliorates Lipopolysaccharide-induced Lung Fibrosis in Acute Respiratory Distress Syndrome", CHINESE JOURNAL OF NEW DRUGS, vol. 25, no. 14, 27 July 2016 (2016-07-27), pages 1652 - 1659, XP055771895, ISSN: 1003-3734
CHAUDHARY N I; ROTH G J; HILBERG F; MUELLER-QUERNHEIM J; PRASSE A; ZISSEL G; SCHNAPP A; PARK J E: "Inhibition of PDGF, VEGF and FGF Signalling Attenuates Fibrosis", EUROPEAN RESPIRATORY JOURNAL, vol. 29, no. 5, 1 May 2007 (2007-05-01), pages 976 - 985, XP009109569, ISSN: 0903-1936, DOI: 10.1183/09031936.00152106
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