Title:
USE OF FBP ALDOLASE IN PREPARATION OF DRUG ACTIVATING AMPK
Document Type and Number:
WIPO Patent Application WO/2018/090851
Kind Code:
A1
Abstract:
Disclosed is the use of FBP aldolase in the preparation of a drug activating AMPK. Also disclosed are the uses of FBP aldolase in the preparation of a drug for inhibiting cholesterol synthesis, a drug for reducing fatty acid synthesis, a drug for preventing and/or treating diabetes, a drug for preventing and/or treating tumours, a drug for preventing and/or treating Parkinson's disease, a drug for preventing and/or treating Alzheimer's disease, or a drug for prolonging the lifespan of an organism. The use of FBP aldolase as a target to develop drugs to activate AMPK overcomes the difficulties of directly using AMPK as a drug target in the prior art and has good application prospects.
Inventors:
LIN SHENGCAI (CN)
ZHANG CHENSONG (CN)
ZHANG CHENSONG (CN)
Application Number:
PCT/CN2017/109647
Publication Date:
May 24, 2018
Filing Date:
November 07, 2017
Export Citation:
Assignee:
UNIV XIAMEN (CN)
International Classes:
C12N9/88; A61P3/04; A61P3/06; A61P3/10; A61P5/50; A61P25/16; A61P25/28; A61P35/00; C12N15/60
Foreign References:
| CN101919839A | 2010-12-22 |
Other References:
ZHANG, C. S.: "Fructose-1, 6-bisphosphate and aldolase mediate glucose sensing by AMPK", NATURE, vol. 548, no. 7665, 19 July 2017 (2017-07-19), pages 112 - 116, XP055605466, ISSN: 0028-0836, DOI: 10.1038/nature23275
GRANDJEAN, G.: "Definition of a Novel Feed-Forward Mechanism for Glyco- lysis-HIFla Signaling in Hypoxic Tumors Highlights Aldolase A as a Therapeu- tic Target", CANCER RESEARCH, vol. 76, no. 14, 3 June 2016 (2016-06-03), pages 4259 - 4269, XP055605481, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-16-0401
DATABASE Nucleotide 15 July 2006 (2006-07-15), STRAUSBERG, R. L.: "Homo sapiens aldolase A, fructose-bisphosphate, mRNA (cDNA clone MGC:17716 IMAGE:3869603), complete cds", XP055605491, Database accession no. BC010660.1.
CAO KE ET AL.: "Progress on Natural AMPK Activator in the Prevention and Treatment of Metabolic Syndrome", LIFE SCIENCE RESEARCH, vol. 18, no. 6, 31 December 2014 (2014-12-31), pages 543 - 549
GRANDJEAN, G.: "Definition of a Novel Feed-Forward Mechanism for Glyco- lysis-HIFla Signaling in Hypoxic Tumors Highlights Aldolase A as a Therapeu- tic Target", CANCER RESEARCH, vol. 76, no. 14, 3 June 2016 (2016-06-03), pages 4259 - 4269, XP055605481, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-16-0401
DATABASE Nucleotide 15 July 2006 (2006-07-15), STRAUSBERG, R. L.: "Homo sapiens aldolase A, fructose-bisphosphate, mRNA (cDNA clone MGC:17716 IMAGE:3869603), complete cds", XP055605491, Database accession no. BC010660.1.
CAO KE ET AL.: "Progress on Natural AMPK Activator in the Prevention and Treatment of Metabolic Syndrome", LIFE SCIENCE RESEARCH, vol. 18, no. 6, 31 December 2014 (2014-12-31), pages 543 - 549
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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