Title:
USE OF GABA ANALOGUES FOR THE MODULATION OF SUBSTANCE P
Document Type and Number:
WIPO Patent Application WO2000067742
Kind Code:
A3
Abstract:
Modulation of substance P by GABA analogs is disclosed. Preferred GABA analog compounds include gabapentin and pregabalin. Methods of this invention include the modulation of substance P, as well as methods for preventing or treating conditions associated with substance P, by administering to an animal an effective amount of one or more GABA analog compounds. Conditions associated with substance P include headaches and migraine, neurogenic inflammation, emesis, nausea and vomiting, cough and bronchitis, obesity, allergy, asthma, hemorrhoids and anal fissures, ulcer, fever, infertility and periodontal disease.
Inventors:
MAGISTRO PHILIP JOHN JR (US)
Application Number:
PCT/US2000/006199
Publication Date:
August 16, 2001
Filing Date:
March 10, 2000
Export Citation:
Assignee:
WARNER LAMBERT CO (US)
MAGISTRO PHILIP JOHN JR (US)
MAGISTRO PHILIP JOHN JR (US)
International Classes:
A61K31/195; A61K31/197; A61K31/215; (IPC1-7): A61K31/195; A61P43/00
Domestic Patent References:
| WO1998003167A1 | 1998-01-29 |
Other References:
PARTRIDGE BRETT J ET AL: "Characterization of the effects of gabapentin and 3-isobutyl-gamma-aminobutyric acid on substance P-induced thermal hyperalgesia.", ANESTHESIOLOGY (HAGERSTOWN), vol. 88, no. 1, January 1998 (1998-01-01), pages 196 - 205, XP000979389, ISSN: 0003-3022
WETZEL C H ET AL: "Use of gabapentin in pain management", ANNALS OF PHARMACOTHERAPY,XX,XX, vol. 31, no. 9, September 1997 (1997-09-01), pages 1082 - 1083, XP002101739, ISSN: 1060-0280
FIELD M J ET AL: "GABAPENTIN (NEURONTIN) AND S-(+)-3-ISOBUTYLGABA REPRESENT A NOVEL CLASS OF SELECTIVE ANTIHYPERALGESIC AGENTS", BRITISH JOURNAL OF PHARMACOLOGY,GB,BASINGSTOKE, HANTS, vol. 121, no. 8, 1997, pages 1513 - 1522, XP002043785, ISSN: 0007-1188
BRYANS JUSTIN S ET AL: "3-substituted GABA analogs with central nervous system activity: A review.", MEDICINAL RESEARCH REVIEWS, vol. 19, no. 2, March 1999 (1999-03-01), pages 149 - 177, XP000979391, ISSN: 0198-6325
WETZEL C H ET AL: "Use of gabapentin in pain management", ANNALS OF PHARMACOTHERAPY,XX,XX, vol. 31, no. 9, September 1997 (1997-09-01), pages 1082 - 1083, XP002101739, ISSN: 1060-0280
FIELD M J ET AL: "GABAPENTIN (NEURONTIN) AND S-(+)-3-ISOBUTYLGABA REPRESENT A NOVEL CLASS OF SELECTIVE ANTIHYPERALGESIC AGENTS", BRITISH JOURNAL OF PHARMACOLOGY,GB,BASINGSTOKE, HANTS, vol. 121, no. 8, 1997, pages 1513 - 1522, XP002043785, ISSN: 0007-1188
BRYANS JUSTIN S ET AL: "3-substituted GABA analogs with central nervous system activity: A review.", MEDICINAL RESEARCH REVIEWS, vol. 19, no. 2, March 1999 (1999-03-01), pages 149 - 177, XP000979391, ISSN: 0198-6325
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