Title:
USE OF GUT MICROBIOTA COMPOSITION IN IMMUNOTHERAPY
Document Type and Number:
WIPO Patent Application WO/2018/171555
Kind Code:
A1
Abstract:
Provided are methods and compositions, e.g., kits, for determining the abundance of certain bacterial species in a cancer patient's gut and methods of using such information to predict the cancer patient's response to immunotherapy. Provided are methods and compositions for improving the efficacy of an immunotherapy in patients.
Inventors:
YANG WENQING (CN)
CHEN FEI (CN)
DING JIAN (CN)
GU XIANGCHAO (CN)
SHI QIAN (CN)
CHEN FEI (CN)
DING JIAN (CN)
GU XIANGCHAO (CN)
SHI QIAN (CN)
Application Number:
PCT/CN2018/079477
Publication Date:
September 27, 2018
Filing Date:
March 19, 2018
Export Citation:
Assignee:
CROWN BIOSCIENCE INC TAICANG (CN)
International Classes:
A61K35/742; A61K35/741; A61K35/745; A61K45/06; A61P35/00
Domestic Patent References:
| WO2016196605A1 | 2016-12-08 |
Other References:
ROUTY, B. ET AL.: "Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors", SCIENCE, vol. 539, no. 6371, 5 January 2018 (2018-01-05), pages 91 - 97, XP055527739
GOPALAKRISHNAN, V. ET AL.: "Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients", SCIENCE, vol. 359, no. 6371, 5 January 2018 (2018-01-05), pages 1 - 20, XP055540905
SIVAN, A. ET AL.: "Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy", SCIENCEXPRESS, vol. 350, no. 6264, 5 November 2015 (2015-11-05), pages 1084 - 1089, XP055310361
VETIZOU, M. ET AL.: "Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota", SCIENCEXPRESS, vol. 350, no. 6264, 5 November 2015 (2015-11-05), pages 1079 - 1084, XP055310374
ZITVOGEL, L. ET AL.: "Cancer and the gut microbiota:An unexpected link", SCIENCE TRANSLATION MEDICINE, vol. 7, no. 271, 21 January 2015 (2015-01-21), pages 1 - 5, XP055333413
GOPALAKRISHNAN, V. ET AL.: "Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients", SCIENCE, vol. 359, no. 6371, 5 January 2018 (2018-01-05), pages 1 - 20, XP055540905
SIVAN, A. ET AL.: "Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy", SCIENCEXPRESS, vol. 350, no. 6264, 5 November 2015 (2015-11-05), pages 1084 - 1089, XP055310361
VETIZOU, M. ET AL.: "Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota", SCIENCEXPRESS, vol. 350, no. 6264, 5 November 2015 (2015-11-05), pages 1079 - 1084, XP055310374
ZITVOGEL, L. ET AL.: "Cancer and the gut microbiota:An unexpected link", SCIENCE TRANSLATION MEDICINE, vol. 7, no. 271, 21 January 2015 (2015-01-21), pages 1 - 5, XP055333413
Attorney, Agent or Firm:
JUN HE LAW OFFICES (CN)
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