Title:
USE OF HOMOVANILLIC ACID AND ANALOG THEREOF IN PREPARATION OF DRUG FOR TREATING DEPRESSION
Document Type and Number:
WIPO Patent Application WO/2024/051835
Kind Code:
A1
Abstract:
Use of homovanillic acid and an analog thereof in the preparation of a drug for treating depression. Use of a substance Z in the preparation of a drug. The substance Z is a compound represented by formula I or a pharmaceutically acceptable salt thereof; the drug is a drug for treating and/or preventing depression; R in formula I is C1-C6 alkoxy, and n is 1, 2, 3, or 4. Homovanillic acid intervention eliminates the significant difference in the bacterial flora of normal mice and chronic stress depression mice at different species levels (e.g., α-diversity). In addition, homovanillic acid shows a good protection effect on cells damaged by sugar deficiency.
Inventors:
JIA WEI (CN)
ZHAO MINGLIANG (CN)
REN ZHENXING (CN)
CHEN TIANLU (CN)
ZHAO MINGLIANG (CN)
REN ZHENXING (CN)
CHEN TIANLU (CN)
Application Number:
PCT/CN2023/117803
Publication Date:
March 14, 2024
Filing Date:
September 08, 2023
Export Citation:
Assignee:
SHANGHAI SIXTH PEOPLES HOSPITAL (CN)
International Classes:
A61K31/192; A61P25/24
Foreign References:
| CN112999214A | 2021-06-22 |
Other References:
KNORR, U. ET AL.: "Low Level of Evidence for Reduced Homovanillic Acid (HVA) in the Cerebrospinal Fluid of Patients with Depression Compared to Healthy Non-psychiatric Control Individuals", JOURNAL OF AFFECTIVE DISORDERS, vol. 257, 5 July 2019 (2019-07-05), XP085779198, DOI: 10.1016/j.jad.2019.07.011
TAI AKIHIRO, SAWANO TAKESHI, YAZAMA FUTOSHI: "Antioxidant Properties of Ethyl Vanillin in Vitro and in Vivo", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, JP, vol. 75, no. 12, 23 December 2011 (2011-12-23), JP , pages 2346 - 2350, XP093147928, ISSN: 0916-8451, DOI: 10.1271/bbb.110524
XIAOQUN HUANG, LIAO XIAOPING: "Research progress on the relationship between intestinal flora and depression", JOURNAL OF PRACTICAL NERVOUS DISEASES, vol. 22, no. 01, 13 March 2019 (2019-03-13), pages 112 - 116, XP093147929
LIWEI ZHANG, WANG SUYAN; GAO YE; SONG RUOBING; ZHANG ZHIYU, HONG LI: "The Neurotransmitter Basis of Negative Attentional Biases:Evidence from a Depressed Rat Model", JOURNAL OF CHINA MEDICAL UNIVERSITY, CHINA MEDICAL UNIVERSITY, SHENYANG,, CN, vol. 48, no. 9, 9 September 2019 (2019-09-09), CN , pages 807 - 811, XP093147932, ISSN: 0258-4646, DOI: 10.12007/j.issn.0258-4646.2019.09.009
ZHANG CHANXI, WANG QINHUI; WANG XIAOHONG; WANG TINGHUA; CHEN LIN: "Effects of orcinol glucoside on methamphetamine -induced anxiety -like behaviors in mice", CHINESE JOURNAL OF DRUG DEPENDENCE, vol. 27, no. 3, 15 June 2018 (2018-06-15), pages 189 - 194, XP093147934
YIJUN WEI, SHAO YIFAN; LI HAIBEI; HSIANG-T'IEN-HSIEN: " Research on the Influence of Depression on Intestinal Flora in Rats", JOURNAL OF PREVENTIVE MEDICINE OF CHINESE PEOPLE'S LIBERATION ARMY, vol. 39, no. 1, 30 January 2021 (2021-01-30), pages 1 - 4, XP093147936, DOI: 10.13704/j.cnki.jyyx.2021.01.001
TAI AKIHIRO, SAWANO TAKESHI, YAZAMA FUTOSHI: "Antioxidant Properties of Ethyl Vanillin in Vitro and in Vivo", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, JP, vol. 75, no. 12, 23 December 2011 (2011-12-23), JP , pages 2346 - 2350, XP093147928, ISSN: 0916-8451, DOI: 10.1271/bbb.110524
XIAOQUN HUANG, LIAO XIAOPING: "Research progress on the relationship between intestinal flora and depression", JOURNAL OF PRACTICAL NERVOUS DISEASES, vol. 22, no. 01, 13 March 2019 (2019-03-13), pages 112 - 116, XP093147929
LIWEI ZHANG, WANG SUYAN; GAO YE; SONG RUOBING; ZHANG ZHIYU, HONG LI: "The Neurotransmitter Basis of Negative Attentional Biases:Evidence from a Depressed Rat Model", JOURNAL OF CHINA MEDICAL UNIVERSITY, CHINA MEDICAL UNIVERSITY, SHENYANG,, CN, vol. 48, no. 9, 9 September 2019 (2019-09-09), CN , pages 807 - 811, XP093147932, ISSN: 0258-4646, DOI: 10.12007/j.issn.0258-4646.2019.09.009
ZHANG CHANXI, WANG QINHUI; WANG XIAOHONG; WANG TINGHUA; CHEN LIN: "Effects of orcinol glucoside on methamphetamine -induced anxiety -like behaviors in mice", CHINESE JOURNAL OF DRUG DEPENDENCE, vol. 27, no. 3, 15 June 2018 (2018-06-15), pages 189 - 194, XP093147934
YIJUN WEI, SHAO YIFAN; LI HAIBEI; HSIANG-T'IEN-HSIEN: " Research on the Influence of Depression on Intestinal Flora in Rats", JOURNAL OF PREVENTIVE MEDICINE OF CHINESE PEOPLE'S LIBERATION ARMY, vol. 39, no. 1, 30 January 2021 (2021-01-30), pages 1 - 4, XP093147936, DOI: 10.13704/j.cnki.jyyx.2021.01.001
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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