Title:
USE OF HUGU CAPSULE IN PREPARATION OF A DRUG FOR TREATING STEROID-INDUCED OSTEONECROSIS OF THE FEMORAL HEAD
Document Type and Number:
WIPO Patent Application WO/2023/197407
Kind Code:
A1
Abstract:
Disclosed is use of a HuGu capsule in the preparation of a drug for treating steroid-induced osteonecrosis of the femoral head. The HuGu capsule is prepared from radix polygoni multiflori preparata, epimedium, radix rehmanniae praeparata, tortoise shell, morinda officinali, eucommia ulmoides, radix dipsaci, rhizoma drynariae, angelica sinensis, and Chinese yam. It is proved in the present invention that the drug can inhibit the high-conversion state of bone metabolism in a model of the steroid-induced osteonecrosis of the femoral head, inhibit bone resorption, improve the internal environment of the femoral head, and regulate the bone metabolism, providing an experimental basis for the treatment of the steroid-induced osteonecrosis of the femoral head.
Inventors:
PAN CUI PING (CN)
HUANG HUI YUN (CN)
FANG SHU LING (CN)
WANG CHUN BIN (CN)
HUANG HUI YUN (CN)
FANG SHU LING (CN)
WANG CHUN BIN (CN)
Application Number:
PCT/CN2022/094928
Publication Date:
October 19, 2023
Filing Date:
May 25, 2022
Export Citation:
Assignee:
GUANGDONG ANNOL PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K9/48; A61K36/8945; A61K35/586; A61K36/185; A61K36/232; A61K36/296; A61K36/46; A61K36/704; A61K36/746; A61K36/804; A61P19/08
Foreign References:
| CN108186852A | 2018-06-22 |
Other References:
ZHU SHUYUN; MA SUYING; YANG KANG; FANG SHUO; ZHAO YUE;: "The Clinical Observation of the Efficacy of Massage Therapy Combined with Traditional Chinese Medicine on Middle-Late Stage Osteonecrosis of the Femoral Head Due to Hormone and Alcohol", JOURNAL OF GLOBAL TRENDS IN PHARMACEUTICAL SCIENCES, ANNAMACHARYA COLLEGE OF PHARMACY, IND, vol. 21, no. 4, 20 April 2015 (2015-04-20), ind , pages 456 - 459, XP009549500, ISSN: 2230-7346
YANG, GUOZHU ET AL.: "Effect of HuGu Capsule on Inflammatory Factors in Rats with Steroid Induced Osteonecrosis of Femoral Head", CHINESE JOURNAL OF OSTEOPOROSIS AND BONE MINERAL RESEARCH, vol. 14, no. 6, 10 November 2021 (2021-11-10), pages 621 - 627, XP009549501
XU, QILIANG: "Clinical Study of Hugu Capsule on Primary Osteoporosis with Deficiency of Kidney Essence", CHINA DOCTORAL DISSERTATIONS AND MASTER’S THESES FULL-TEXT DATABASE (MASTER), MEDICINE AND HEALTH SCIENCES, no. 4, 15 April 2020 (2020-04-15)
WANG XIAODONG, DONG QUNWEI, HONG MANJIE,ET AL: "Effect of Hugu Capsule on BMD and Histomorphometry in Glucocorticoid-Induced Osteoporotic Rats", CHINESE JOURNAL OF OSTEOPOROSIS, vol. 18, no. 10, 20 October 2012 (2012-10-20), pages 880 - 882+ 879, XP009549499, ISSN: 1006-7108
HU LINGPING, HONG MANJIE, HU MINHUA, SUN PING: "Study on Measurement of Bone Mineral Density and Bone Morphology in Rats with Hormone-Induced Osteoporosis by Compound Hugu Capsule", DANGDAI YIXUE = CHINESE JOURNAL OF INTERVEATION / INTERVENTIONAL RADIOLOGY / CHINA CONTEMPORARY MEDICINE, DANGDAI YIXUE, CHINA, vol. 18, no. 22, 5 August 2012 (2012-08-05), China , pages 23 - 24, XP009549544, ISSN: 1009-4393
YANG, GUOZHU ET AL.: "Effect of Hugu Capsules on Steroid-Induced Osteonecrosis of Femoral Head in Rats", SHANDONG MEDICAL JOURNAL, vol. 62, no. 14, 15 May 2022 (2022-05-15)
YANG, GUOZHU ET AL.: "Effect of HuGu Capsule on Inflammatory Factors in Rats with Steroid Induced Osteonecrosis of Femoral Head", CHINESE JOURNAL OF OSTEOPOROSIS AND BONE MINERAL RESEARCH, vol. 14, no. 6, 10 November 2021 (2021-11-10), pages 621 - 627, XP009549501
XU, QILIANG: "Clinical Study of Hugu Capsule on Primary Osteoporosis with Deficiency of Kidney Essence", CHINA DOCTORAL DISSERTATIONS AND MASTER’S THESES FULL-TEXT DATABASE (MASTER), MEDICINE AND HEALTH SCIENCES, no. 4, 15 April 2020 (2020-04-15)
WANG XIAODONG, DONG QUNWEI, HONG MANJIE,ET AL: "Effect of Hugu Capsule on BMD and Histomorphometry in Glucocorticoid-Induced Osteoporotic Rats", CHINESE JOURNAL OF OSTEOPOROSIS, vol. 18, no. 10, 20 October 2012 (2012-10-20), pages 880 - 882+ 879, XP009549499, ISSN: 1006-7108
HU LINGPING, HONG MANJIE, HU MINHUA, SUN PING: "Study on Measurement of Bone Mineral Density and Bone Morphology in Rats with Hormone-Induced Osteoporosis by Compound Hugu Capsule", DANGDAI YIXUE = CHINESE JOURNAL OF INTERVEATION / INTERVENTIONAL RADIOLOGY / CHINA CONTEMPORARY MEDICINE, DANGDAI YIXUE, CHINA, vol. 18, no. 22, 5 August 2012 (2012-08-05), China , pages 23 - 24, XP009549544, ISSN: 1009-4393
YANG, GUOZHU ET AL.: "Effect of Hugu Capsules on Steroid-Induced Osteonecrosis of Femoral Head in Rats", SHANDONG MEDICAL JOURNAL, vol. 62, no. 14, 15 May 2022 (2022-05-15)
Attorney, Agent or Firm:
GUANGZHOU KEWOYUAN PATENT AGENCY CO., LTD. (CN)
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