Title:
USE OF INDAZOLE COMPOUND IN TREATMENT OF INFLAMMASOME ACTIVATION-MEDIATED DISEASES
Document Type and Number:
WIPO Patent Application WO/2024/099346
Kind Code:
A1
Abstract:
The present invention provides use of a compound as represented by formula I or a pharmaceutically acceptable salt or ester thereof in the preparation of a drug for treating ASC-caspase-1 pathway-based inflammasome activation-mediated diseases. In particular, the compound of the present invention is preferably lonidamine, and is used for treating gout, multiple sclerosis or septicemia.
Inventors:
YIN WEI (CN)
CHEN CHEN (CN)
HUANG YIJUN (CN)
YAN GUANGMEI (CN)
CHEN CHEN (CN)
HUANG YIJUN (CN)
YAN GUANGMEI (CN)
Application Number:
PCT/CN2023/130416
Publication Date:
May 16, 2024
Filing Date:
November 08, 2023
Export Citation:
Assignee:
UNIV SUN YAT SEN (CN)
International Classes:
A61K31/4439; A61K31/415; A61K31/416; A61P7/00; A61P11/06; A61P19/06; A61P25/00; A61P37/08; C07K14/47; C12Q1/68
Domestic Patent References:
| WO2022061008A2 | 2022-03-24 |
Foreign References:
| CN110114351A | 2019-08-09 |
Other References:
CHEN CHEN, ZHOU YUWEI; NING XINPENG; LI SHENGLONG; XUE DONGDONG; WEI CAILV; ZHU ZHU; SHENG LONGXIANG; LU BINGZHENG; LI YUAN; YE XI: "Directly targeting ASC by lonidamine alleviates inflammasome-driven diseases", JOURNAL OF NEUROINFLAMMATION, BIOMED CENTRAL LTD., LONDON, GB, vol. 19, no. 1, GB , XP093170266, ISSN: 1742-2094, DOI: 10.1186/s12974-022-02682-w
SORIANO-TERUEL PAULA M, GARCÍA‑LAÍNEZ GUILLERMO; MARCO-SALVADOR MARÍA; PARDO JULIÁN; ARIAS MAYKEL; DEFORD CHRISTIAN; MERFORT IRMGA: "Identification of an ASC oligomerization inhibitor for the treatment of inflammatory diseases", CELL DEATH & DISEASE, NATURE PUBLISHING GROUP, GB, vol. 12, no. 12, GB , XP093170272, ISSN: 2041-4889, DOI: 10.1038/s41419-021-04420-1
LI YANG, FU TIAN-MIN; LU ALVIN; WITT KRISTEN; RUAN JIANBIN; SHEN CHEN; WU HAO: "Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 115, no. 43, 23 October 2018 (2018-10-23), pages 10845 - 10852, XP093170274, ISSN: 0027-8424, DOI: 10.1073/pnas.1810524115
SORIANO-TERUEL PAULA M, GARCÍA‑LAÍNEZ GUILLERMO; MARCO-SALVADOR MARÍA; PARDO JULIÁN; ARIAS MAYKEL; DEFORD CHRISTIAN; MERFORT IRMGA: "Identification of an ASC oligomerization inhibitor for the treatment of inflammatory diseases", CELL DEATH & DISEASE, NATURE PUBLISHING GROUP, GB, vol. 12, no. 12, GB , XP093170272, ISSN: 2041-4889, DOI: 10.1038/s41419-021-04420-1
LI YANG, FU TIAN-MIN; LU ALVIN; WITT KRISTEN; RUAN JIANBIN; SHEN CHEN; WU HAO: "Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 115, no. 43, 23 October 2018 (2018-10-23), pages 10845 - 10852, XP093170274, ISSN: 0027-8424, DOI: 10.1073/pnas.1810524115
Attorney, Agent or Firm:
WINGUAN PATENT AND TRADEMARK ATTORNEYS (CN)
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