Title:
USE OF INDIRUBINE DERIVATIVES FOR MAKING MEDICINES
Document Type and Number:
WIPO Patent Application WO2001037819
Kind Code:
A3
Abstract:
The invention concerns the use of indirubine derivatives for making medicines inhibiting GSK-3 beta . The invention is useful for treating pathologies involving GSK-3 beta and CDK5.
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Inventors:
EISENBRAND GERHARD (DE)
MEIJER LAURENT (FR)
HOESSEL RALPH (DE)
THOMMET ANDREA (FR)
MEIJER LAURENT (FR)
HOESSEL RALPH (DE)
THOMMET ANDREA (FR)
Application Number:
PCT/FR2000/003264
Publication Date:
June 13, 2002
Filing Date:
November 23, 2000
Export Citation:
Assignee:
CENTRE NAT RECH SCIENT (FR)
EISENBRAND GERHARD (DE)
MEIJER LAURENT (FR)
HOESSEL RALPH (DE)
THOMMET ANDREA (FR)
EISENBRAND GERHARD (DE)
MEIJER LAURENT (FR)
HOESSEL RALPH (DE)
THOMMET ANDREA (FR)
International Classes:
A61K31/00; A61K31/404; A61P3/10; A61P9/00; A61P13/12; A61P17/06; A61P25/18; A61P25/28; A61P31/04; A61P31/10; A61P31/12; A61P33/00; A61P35/00; A61P39/00; A61P43/00; C07D209/34; (IPC1-7): A61K31/404; A61K31/00; A61P3/10; A61P25/28; A61P31/10; A61P33/00; A61P35/00; A61P39/00
Domestic Patent References:
| WO1997041854A1 | 1997-11-13 |
Foreign References:
| EP0966963A1 | 1999-12-29 |
Other References:
HOESSEL R ET AL: "INDIRUBIN, THE ACTIVE CONSTITUENT OF A CHINESE ANTILEUKAEMIA MEDICINE, INHIBITS CYCLIN-DEPENDENT KINASES", NATURE CELL BIOLOGY, MACMILLAN PUBLISHERS, GB, vol. 1, no. 1, 1 May 1999 (1999-05-01), pages 60 - 67, XP000856197, ISSN: 1465-7392
MEIJER L. ET AL: "Properties and potential applications of chemical inhibitors of cyclin-dependent Kinases.", PHARMACOLOGY AND THERAPEUTICS, (1999) 82/2 (279-284)., XP000938154
GRAY N ET AL: "ATP-SITE DIRECTED INHIBITORS OF CYCLIN-DEPENDENT KINASES", CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, vol. 6, no. 9, September 1999 (1999-09-01), pages 859 - 875, XP000856195, ISSN: 0929-8673
MEIJER L.: "Cyclin-dependent kinases inhibitors as potential anticancer, antineurodegenerative, antiviral and antiparasitic agents.", DRUG RESISTANCE UPDATES, (2000) 3/2 (83-88)., XP000931278
MEIJER L. ET AL: "Properties and potential applications of chemical inhibitors of cyclin-dependent Kinases.", PHARMACOLOGY AND THERAPEUTICS, (1999) 82/2 (279-284)., XP000938154
GRAY N ET AL: "ATP-SITE DIRECTED INHIBITORS OF CYCLIN-DEPENDENT KINASES", CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, vol. 6, no. 9, September 1999 (1999-09-01), pages 859 - 875, XP000856195, ISSN: 0929-8673
MEIJER L.: "Cyclin-dependent kinases inhibitors as potential anticancer, antineurodegenerative, antiviral and antiparasitic agents.", DRUG RESISTANCE UPDATES, (2000) 3/2 (83-88)., XP000931278
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