USE OF IONIZABLE CATIONIC LIPID ANALOG MATERIAL AS PROTEIN DRUG DELIVERY CARRIER

Title:

USE OF IONIZABLE CATIONIC LIPID ANALOG MATERIAL AS PROTEIN DRUG DELIVERY CARRIER

Document Type and Number:

WIPO Patent Application WO/2022/170834

Kind Code:

A1

Abstract:

Disclosed in the present invention is the use of an ionizable cationic lipid analog material as a protein drug delivery carrier. The cationic lipid analog material of the present invention has an efficient capability of intracellular delivery of a protein, is effective for proteins with different molecular weights and charges, and can still maintain the biological activity of the protein when delivering the protein into a cell. Moreover, the material has low toxicity to the cell and good biocompatibility, and can be used as a protein drug delivery carrier.

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Inventors:

LIU ZHIJIA (CN)
LE ZHICHENG (CN)
CHEN YONGMING (CN)

Application Number:

PCT/CN2021/136179

Publication Date:

August 18, 2022

Filing Date:

December 07, 2021

Export Citation:

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Assignee:

UNIV SUN YAT SEN (CN)

International Classes:

A61K47/18; A61K9/51; A61K45/00; A61K47/22; C07C231/06; C07D207/14; C07D295/13

Foreign References:

CN111892707A	2020-11-06
CN106117548A	2016-11-16
CN107619477A	2018-01-23
US20150197675A1	2015-07-16

Attorney, Agent or Firm:

SCIHEAD IP LAW FIRM (CN)

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