Title:
USE OF IRON-CONTAINING MATERIAL IN PREPARATION OF PRODUCT FOR INHIBITING TRANSMISSION OF DENGUE VIRUS
Document Type and Number:
WIPO Patent Application WO/2021/027181
Kind Code:
A1
Abstract:
Disclosed is the use of an iron-containing material in the preparation of a product for inhibiting the transmission of dengue virus and/or inhibiting the susceptibility of mosquitoes to dengue virus. Hosts with different iron statuses that have been bitten by Aedes aegypti and infected with the dengue virus have different viral infection rates, and the susceptibility of Aedes aegypti to the dengue virus is negatively correlated with an iron status of the blood of a host. The iron supplementation for an iron-deficient mouse model can reduce the susceptibility of same to dengue virus triggered by Aedes aegypti, indicating that an iron-containing material can reduce the ability of Aedes aegypti to carry a virus and can block the spread of the virus.
Inventors:
CHENG GONG (CN)
ZHU YIBIN (CN)
ZHU YIBIN (CN)
Application Number:
PCT/CN2019/120582
Publication Date:
February 18, 2021
Filing Date:
November 25, 2019
Export Citation:
Assignee:
UNIV TSINGHUA (CN)
International Classes:
A61K33/26; A61P31/14
Domestic Patent References:
| WO1995011033A1 | 1995-04-27 | |||
| WO2015145380A2 | 2015-10-01 |
Foreign References:
| CN108014129A | 2018-05-11 |
Other References:
CHEN HONG, CHEN HAN BIN: "Changes in Element Content in Aedes albopictus Infected by Dengue Virus Type II", CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, ZHONGGUO YUFANG YIXUE KEXUEYUAN JISHENGCHONGBING YANJIUSUO, CN, vol. 20, no. 3, 30 June 2002 (2002-06-30), CN, pages 171 - 173, XP055780630, ISSN: 1000-7423
DUCHEMIN JEAN-BERNARD, PARADKAR PRASAD N: "Iron availability affects West Nile virus infection in its mosquito vector", VIROLOGY JOURNAL, vol. 14, no. 1, 103, 1 December 2017 (2017-12-01), pages 1 - 9, XP055780625, DOI: 10.1186/s12985-017-0770-0
DUCHEMIN JEAN-BERNARD, PARADKAR PRASAD N: "Iron availability affects West Nile virus infection in its mosquito vector", VIROLOGY JOURNAL, vol. 14, no. 1, 103, 1 December 2017 (2017-12-01), pages 1 - 9, XP055780625, DOI: 10.1186/s12985-017-0770-0
Attorney, Agent or Firm:
JEEKAI & PARTNERS (CN)
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