Title:
USE OF ISOQUINOLINE ALKALOID IN PREVENTION AND TREATMENT OF DISEASES CAUSED BY CORONAVIRAL INFECTIONS
Document Type and Number:
WIPO Patent Application WO/2024/088403
Kind Code:
A1
Abstract:
The present invention relates to a new use of an isoquinoline alkaloid and a pharmaceutically acceptable salt thereof in medicine, and in particular to a use of an isoquinoline alkaloid compound and a pharmaceutically acceptable salt thereof in the prevention, alleviation and/or treatment of SARS-CoV-2 viral infectious diseases. Experimental results show that the isoquinoline alkaloid obviously inhibits virus infection and replication on an anti-SARS-CoV-2 virus drug screening model, i.e., pangolin coronavirus strain xCoV, a SARS-CoV-2 virus-like particle (trVLP) system, and a VSV pseudovirus system. The isoquinoline alkaloid inhibits virus replication by inhibiting the whole life cycle of the virus, and the results strongly indicate the potential clinical application values of the isoquinoline alkaloid for diseases caused by the currently popular novel coronavirus and other coronaviral infections.
Inventors:
TONG YIGANG (CN)
CHEN SHILIN (CN)
FAN HUAHAO (CN)
LENG LIANG (CN)
XU ZHICHAO (CN)
SONG CHI (CN)
ZOU ZHONGMEI (CN)
HONG BIXIA (CN)
LIU KE (CN)
CHEN SHILIN (CN)
FAN HUAHAO (CN)
LENG LIANG (CN)
XU ZHICHAO (CN)
SONG CHI (CN)
ZOU ZHONGMEI (CN)
HONG BIXIA (CN)
LIU KE (CN)
Application Number:
PCT/CN2023/127237
Publication Date:
May 02, 2024
Filing Date:
October 27, 2023
Export Citation:
Assignee:
UNIV BEIJING CHEM TECH (CN)
UNIV CHENGDU TRADITIONAL CHINESE MEDICINE (CN)
UNIV NORTHEAST FORESTRY (CN)
INST MED PLANT DEV CAMS (CN)
UNIV CHENGDU TRADITIONAL CHINESE MEDICINE (CN)
UNIV NORTHEAST FORESTRY (CN)
INST MED PLANT DEV CAMS (CN)
International Classes:
A61K31/4748; A61K31/47; A61P11/00; A61P31/14
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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